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10.1038/s41579-021-00630-8 http://scihub22266oqcxt.onion/10.1038/s41579-021-00630-8 34535791!8447893!34535791     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Microbiol 2021 ; 19 (11): 685-700 Nephropedia Template TP {{tp|p=34535791|t=2021. Structural biology of SARS-CoV-2 and implications for therapeutic development |pdf=|usr=}}{{34535791}} gab.com Text Structural biology of SARS-CoV-2 and implications for therapeutic development JO: Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34535791 #FOAvip The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach for treating COVID-19. Belonging to the subfamily Orthocoronavirinae with the largest RNA genome, SARS-CoV-2 encodes a total of 29 proteins. These non-structural, structural and accessory proteins participate in entry into host cells, genome replication and transcription, and viral assembly and release. SARS-CoV-2 proteins can individually perform essential physiological roles, be components of the viral replication machinery or interact with numerous host cellular factors. In this Review, we delineate the structural features of SARS-CoV-2 from the whole viral particle to the individual viral proteins and discuss their functions as well as their potential as targets for therapeutic interventions. Twit Text FOAVip Structural biology of SARS-CoV-2 and implications for therapeutic development ????Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34535791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34535791 #FOAvip English Wikipedia <ref>{{Cite pmid|34535791}}</ref> Structural biology of SARS-CoV-2 and implications for therapeutic development #MMPMID34535791 Yang H; Rao Z Nat Rev Microbiol 2021[Nov]; 19 (11): 685-700 PMID34535791show ga The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach for treating COVID-19. Belonging to the subfamily Orthocoronavirinae with the largest RNA genome, SARS-CoV-2 encodes a total of 29 proteins. These non-structural, structural and accessory proteins participate in entry into host cells, genome replication and transcription, and viral assembly and release. SARS-CoV-2 proteins can individually perform essential physiological roles, be components of the viral replication machinery or interact with numerous host cellular factors. In this Review, we delineate the structural features of SARS-CoV-2 from the whole viral particle to the individual viral proteins and discuss their functions as well as their potential as targets for therapeutic interventions. |*COVID-19 Drug Treatment[MESH] |COVID-19/virology[MESH] |Drug Delivery Systems[MESH] |Genome, Viral[MESH] |SARS-CoV-2/*chemistry/drug effects/genetics/physiology[MESH]Structural biology of SARS-CoV-2 and implications for therapeutic deve(epmc).pdf DeepDyve Pubget Overpricing