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10.1111/imm.13416 http://scihub22266oqcxt.onion/10.1111/imm.13416 34534359!8561098!34534359     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34534359&cmd=llinks): Failed to open stream: HTTP request failed! 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The role of Bruton s tyrosine kinase in the immune system and disease |pdf=|usr=}}{{34534359}} gab.com Text The role of Bruton s tyrosine kinase in the immune system and disease JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34534359 #FOAvip Bruton's tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B-cell biology and function, highlighted by its position as a critical component of the B-cell receptor signalling pathway. Due to its role as a therapeutic target in several haematological malignancies including chronic lymphocytic leukaemia, BTK has been gaining tremendous momentum in recent years. Within the immune system, BTK plays a part in numerous pathways and cells beyond B cells (i.e. T cells, macrophages). Not surprisingly, BTK has been elucidated to be a driving factor not only in lymphoproliferative disorders but also in autoimmune diseases and response to infection. To extort this role, BTK inhibitors such as ibrutinib have been developed to target BTK in other diseases. However, due to rising levels of resistance, the urgency to develop new inhibitors with alternative modes of targeting BTK is high. To meet this demand, an expanding list of BTK inhibitors is currently being trialled. In this review, we synopsize recent discoveries regarding BTK and its role within different immune cells and pathways. Additionally, we discuss the broad significance and relevance of BTK for various diseases ranging from haematology and rheumatology to the COVID-19 pandemic. Overall, BTK signalling and its targetable nature have emerged as immensely important for a wide range of clinical applications. The development of novel, more specific and less toxic BTK inhibitors could be revolutionary for a significant number of diseases with yet unmet treatment needs. Twit Text FOAVip The role of Bruton s tyrosine kinase in the immune system and disease ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34534359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34534359 #FOAvip English Wikipedia <ref>{{Cite pmid|34534359}}</ref> The role of Bruton s tyrosine kinase in the immune system and disease #MMPMID34534359 McDonald C; Xanthopoulos C; Kostareli E Immunology 2021[Dec]; 164 (4): 722-736 PMID34534359show ga Bruton's tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B-cell biology and function, highlighted by its position as a critical component of the B-cell receptor signalling pathway. Due to its role as a therapeutic target in several haematological malignancies including chronic lymphocytic leukaemia, BTK has been gaining tremendous momentum in recent years. Within the immune system, BTK plays a part in numerous pathways and cells beyond B cells (i.e. T cells, macrophages). Not surprisingly, BTK has been elucidated to be a driving factor not only in lymphoproliferative disorders but also in autoimmune diseases and response to infection. To extort this role, BTK inhibitors such as ibrutinib have been developed to target BTK in other diseases. However, due to rising levels of resistance, the urgency to develop new inhibitors with alternative modes of targeting BTK is high. To meet this demand, an expanding list of BTK inhibitors is currently being trialled. In this review, we synopsize recent discoveries regarding BTK and its role within different immune cells and pathways. Additionally, we discuss the broad significance and relevance of BTK for various diseases ranging from haematology and rheumatology to the COVID-19 pandemic. Overall, BTK signalling and its targetable nature have emerged as immensely important for a wide range of clinical applications. The development of novel, more specific and less toxic BTK inhibitors could be revolutionary for a significant number of diseases with yet unmet treatment needs. |Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors/*metabolism[MESH] |Animals[MESH] |Autoimmune Diseases/drug therapy/enzymology/immunology[MESH] |B-Lymphocytes/drug effects/*enzymology/immunology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/enzymology/immunology[MESH] |Humans[MESH] |Immune System/drug effects/*enzymology/immunology[MESH] |Lymphoproliferative Disorders/drug therapy/enzymology/immunology[MESH] |Molecular Targeted Therapy[MESH] |Protein Kinase Inhibitors/therapeutic use[MESH] |Receptors, Antigen, B-Cell/metabolism[MESH] |Receptors, Chemokine/metabolism[MESH] |Signal Transduction[MESH]The role of Bruton s tyrosine kinase in the immune system and disease (epmc).pdf DeepDyve Pubget Overpricing