Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2021.718744 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.718744 34531865!8439578!34531865     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 718744 Nephropedia Template TP {{tp|p=34531865|t=2021. Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome |pdf=|usr=}}{{34531865}} gab.com Text Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34531865 #FOAvip COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, the underlying pathogenesis is unclear. We aimed to provide novel immunological and genetic descriptions of MIS-A patients. Cytokine responses (IL-6, IL-1beta, TNFalpha, CXCL10, type I, II and III interferons) following SARS-CoV-2 infection of peripheral blood mononuclear cells in vitro were analyzed as well as antibodies against IFNalpha and IFNomega (by ELISA) in patients and healthy controls. We also performed whole exome sequencing (WES) of patient DNA. A total of five patients (ages 19, 23, 33, 38, 50 years) were included. The patients shared characteristic features, although organ involvement and the time course of disease varied slightly. SARS-CoV-2 in vitro infection of patient PBMCs revealed impaired type I and III interferon responses and reduced CXCL10 expression, whereas production of proinflammatory cytokines were less affected, compared to healthy controls. Presence of interferon autoantibodies was not detected. Whole exome sequencing analysis of patient DNA revealed 12 rare potentially disease-causing variants in genes related to autophagy, classical Kawasaki disease, restriction factors and immune responses. In conclusion, we observed an impaired production of type I and III interferons in response to SARS-CoV-2 infection and detected several rare potentially disease-causing gene variants potentially contributing to MIS-A. Twit Text FOAVip Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34531865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34531865 #FOAvip English Wikipedia <ref>{{Cite pmid|34531865}}</ref> Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome #MMPMID34531865 Ronit A; Jorgensen SE; Roed C; Eriksson R; Iepsen UW; Plovsing RR; Storgaard M; Gustafsson F; Hansen AE; Mogensen TH Front Immunol 2021[]; 12 (ä): 718744 PMID34531865show ga COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, the underlying pathogenesis is unclear. We aimed to provide novel immunological and genetic descriptions of MIS-A patients. Cytokine responses (IL-6, IL-1beta, TNFalpha, CXCL10, type I, II and III interferons) following SARS-CoV-2 infection of peripheral blood mononuclear cells in vitro were analyzed as well as antibodies against IFNalpha and IFNomega (by ELISA) in patients and healthy controls. We also performed whole exome sequencing (WES) of patient DNA. A total of five patients (ages 19, 23, 33, 38, 50 years) were included. The patients shared characteristic features, although organ involvement and the time course of disease varied slightly. SARS-CoV-2 in vitro infection of patient PBMCs revealed impaired type I and III interferon responses and reduced CXCL10 expression, whereas production of proinflammatory cytokines were less affected, compared to healthy controls. Presence of interferon autoantibodies was not detected. Whole exome sequencing analysis of patient DNA revealed 12 rare potentially disease-causing variants in genes related to autophagy, classical Kawasaki disease, restriction factors and immune responses. In conclusion, we observed an impaired production of type I and III interferons in response to SARS-CoV-2 infection and detected several rare potentially disease-causing gene variants potentially contributing to MIS-A. |Adult[MESH] |Autoantibodies/blood[MESH] |COVID-19/*pathology[MESH] |Chemokine CXCL10/biosynthesis[MESH] |Comorbidity[MESH] |Cytokines/*blood[MESH] |Exome Sequencing[MESH] |Exome/genetics[MESH] |Female[MESH] |Humans[MESH] |Interferon Lambda[MESH] |Interferon-alpha/*biosynthesis/immunology[MESH] |Interferons/*biosynthesis/immunology[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH] |Systemic Inflammatory Response Syndrome/*pathology[MESH]Host Genetics and Antiviral Immune Responses in Adult Patients With Mu(epmc).pdf DeepDyve Pubget Overpricing