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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Signal+Transduct+Target+Ther 2021 ; 6 (1): 342 Nephropedia Template TP
Zhao XN; You Y; Cui XM; Gao HX; Wang GL; Zhang SB; Yao L; Duan LJ; Zhu KL; Wang YL; Li L; Lu JH; Wang HB; Fan JF; Zheng HW; Dai EH; Tian LY; Ma MJ
Signal Transduct Target Ther 2021[Sep]; 6 (1): 342 PMID34531370show ga
While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. We performed single-cell transcriptome and T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, and severe patients with healthy controls. Asymptomatic patients displayed increased CD56(bri)CD16(-) natural killer (NK) cells and upregulation of interferon-gamma in effector CD4(+) and CD8(+) T cells and NK cells. They showed more robust TCR clonal expansion, especially in effector CD4(+) T cells, but lack strong BCR clonal expansion compared to moderate patients. Moreover, asymptomatic patients have lower interferon-stimulated genes (ISGs) expression in general but large interpatient variability, whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease. Our data provide evidence of different immune signatures to SARS-CoV-2 in asymptomatic infections.