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10.1016/j.gene.2021.145963 http://scihub22266oqcxt.onion/10.1016/j.gene.2021.145963 34530086!8437745!34530086     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2022 ; 808 (ä): 145963 Nephropedia Template TP {{tp|p=34530086|t=2022. An overview of human proteins and genes involved in SARS-CoV-2 infection |pdf=|usr=}}{{34530086}} gab.com Text An overview of human proteins and genes involved in SARS-CoV-2 infection JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=34530086 #FOAvip As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally. Complications of severe COVID-19 include acute kidney injury, liver dysfunction, cardiomyopathy, and coagulation dysfunction. Thus, there is an urgent need to identify proteins and genetic factors associated with COVID-19 susceptibility and outcome. We comprehensively reviewed recent findings of host-SARS-CoV-2 interactome analyses. To identify genetic variants associated with COVID-19, we focused on the findings from genome and transcriptome wide association studies (GWAS and TWAS) and bioinformatics analysis. We described established human proteins including ACE2, TMPRSS2, 40S ribosomal subunit, ApoA1, TOM70, HLA-A, and PALS1 interacting with SARS-CoV-2 based on cryo-electron microscopy results. Furthermore, we described approximately 1000 human proteins showing evidence of interaction with SARS-CoV-2 and highlighted host cellular processes such as innate immune pathways affected by infection. We summarized the evidence on more than 20 identified candidate genes in COVID-19 severity. Predicted deleterious and disruptive genetic variants with possible effects on COVID-19 infectivity have been also summarized. These findings provide novel insights into SARS-CoV-2 biology and infection as well as potential strategies for development of novel COVID therapeutic targets and drug repurposing. Twit Text FOAVip An overview of human proteins and genes involved in SARS-CoV-2 infection ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=34530086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34530086 #FOAvip English Wikipedia <ref>{{Cite pmid|34530086}}</ref> An overview of human proteins and genes involved in SARS-CoV-2 infection #MMPMID34530086 Jahanafrooz Z; Chen Z; Bao J; Li H; Lipworth L; Guo X Gene 2022[Jan]; 808 (ä): 145963 PMID34530086show ga As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally. Complications of severe COVID-19 include acute kidney injury, liver dysfunction, cardiomyopathy, and coagulation dysfunction. Thus, there is an urgent need to identify proteins and genetic factors associated with COVID-19 susceptibility and outcome. We comprehensively reviewed recent findings of host-SARS-CoV-2 interactome analyses. To identify genetic variants associated with COVID-19, we focused on the findings from genome and transcriptome wide association studies (GWAS and TWAS) and bioinformatics analysis. We described established human proteins including ACE2, TMPRSS2, 40S ribosomal subunit, ApoA1, TOM70, HLA-A, and PALS1 interacting with SARS-CoV-2 based on cryo-electron microscopy results. Furthermore, we described approximately 1000 human proteins showing evidence of interaction with SARS-CoV-2 and highlighted host cellular processes such as innate immune pathways affected by infection. We summarized the evidence on more than 20 identified candidate genes in COVID-19 severity. Predicted deleterious and disruptive genetic variants with possible effects on COVID-19 infectivity have been also summarized. These findings provide novel insights into SARS-CoV-2 biology and infection as well as potential strategies for development of novel COVID therapeutic targets and drug repurposing. |COVID-19/*metabolism/physiopathology[MESH] |Computational Biology/methods[MESH] |Cryoelectron Microscopy/methods[MESH] |Crystallography, X-Ray/methods[MESH] |Genome-Wide Association Study[MESH] |Host Microbial Interactions/*genetics/physiology[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Proteins/metabolism[MESH]An overview of human proteins and genes involved in SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing