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10.1183/16000617.0059-2021 http://scihub22266oqcxt.onion/10.1183/16000617.0059-2021 34526314!9489056!34526314     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Respir+Rev 2021 ; 30 (161): ä Nephropedia Template TP {{tp|p=34526314|t=2021. Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome |pdf=|usr=}}{{34526314}} gab.com Text Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome JO: Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=34526314 #FOAvip Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ARDS is characterised by diffuse alveolar damage that leads to protein-rich pulmonary oedema, local alveolar hypoventilation and atelectasis. Inadequate perfusion of these areas is the main cause of hypoxaemia in ARDS. High perfusion in relation to ventilation (V/Q<1) and shunting (V/Q=0) is not only caused by impaired hypoxic pulmonary vasoconstriction but also redistribution of perfusion from obstructed lung vessels. Rebalancing the pulmonary vascular tone is a therapeutic challenge. Previous clinical trials on inhaled vasodilators (nitric oxide and prostacyclin) to enhance perfusion to high V/Q areas showed beneficial effects on hypoxaemia but not on mortality. However, specific patient populations with pulmonary hypertension may profit from treatment with inhaled vasodilators. Novel treatment targets to decrease perfusion in low V/Q areas include epoxyeicosatrienoic acids and specific leukotriene receptors. Still, lung protective ventilation and prone positioning are the best available standard of care. This review focuses on disturbed perfusion in ARDS and aims to provide basic scientists and clinicians with an overview of the vascular alterations and mechanisms of V/Q mismatch, current therapeutic strategies, and experimental approaches. Twit Text FOAVip Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome ????Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=34526314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34526314 #FOAvip English Wikipedia <ref>{{Cite pmid|34526314}}</ref> Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome #MMPMID34526314 Gierhardt M; Pak O; Walmrath D; Seeger W; Grimminger F; Ghofrani HA; Weissmann N; Hecker M; Sommer N Eur Respir Rev 2021[Sep]; 30 (161): ä PMID34526314show ga Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ARDS is characterised by diffuse alveolar damage that leads to protein-rich pulmonary oedema, local alveolar hypoventilation and atelectasis. Inadequate perfusion of these areas is the main cause of hypoxaemia in ARDS. High perfusion in relation to ventilation (V/Q<1) and shunting (V/Q=0) is not only caused by impaired hypoxic pulmonary vasoconstriction but also redistribution of perfusion from obstructed lung vessels. Rebalancing the pulmonary vascular tone is a therapeutic challenge. Previous clinical trials on inhaled vasodilators (nitric oxide and prostacyclin) to enhance perfusion to high V/Q areas showed beneficial effects on hypoxaemia but not on mortality. However, specific patient populations with pulmonary hypertension may profit from treatment with inhaled vasodilators. Novel treatment targets to decrease perfusion in low V/Q areas include epoxyeicosatrienoic acids and specific leukotriene receptors. Still, lung protective ventilation and prone positioning are the best available standard of care. This review focuses on disturbed perfusion in ARDS and aims to provide basic scientists and clinicians with an overview of the vascular alterations and mechanisms of V/Q mismatch, current therapeutic strategies, and experimental approaches. |*COVID-19/complications[MESH] |*Respiratory Distress Syndrome/diagnosis/etiology/therapy[MESH] |Humans[MESH] |Hypoxia[MESH] |Lung/physiopathology[MESH] |SARS-CoV-2[MESH]Impairment of hypoxic pulmonary vasoconstriction in acute respiratory (epmc).pdf DeepDyve Pubget Overpricing