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10.1128/mSystems.00388-21 http://scihub22266oqcxt.onion/10.1128/mSystems.00388-21 34519533!8547474!34519533     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34519533&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34519533.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       mSystems 2021 ; 6 (5): e0038821 Nephropedia Template TP {{tp|p=34519533|t=2021. Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches |pdf=|usr=}}{{34519533}} gab.com Text Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches JO: mSystems http://www.kidney.de/pget.php?&tw=1&pmid=34519533 #FOAvip Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens, such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic, represent major global health challenges. While vaccination is an important part of the arsenal to counter the spread of viral diseases, it presents limitations and needs to be complemented by efficient therapeutic solutions. Intricate knowledge of host-pathogen interactions is a powerful tool to identify host-dependent vulnerabilities that can be exploited to dampen viral replication. Such host-directed antiviral therapies are promising and are less prone to the development of drug-resistant viral strains. Here, we first describe proteomics-based strategies that allow the rapid characterization of host-pathogen interactions. We then discuss how such data can be exploited to help prioritize compounds with potential host-directed antiviral activity that can be tested in preclinical models. Twit Text FOAVip Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches ????mSystems http://www.kidney.de/pget.php?&tw=1&pmid=34519533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34519533 #FOAvip English Wikipedia <ref>{{Cite pmid|34519533}}</ref> Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches #MMPMID34519533 Cakir M; Obernier K; Forget A; Krogan NJ mSystems 2021[Oct]; 6 (5): e0038821 PMID34519533show ga Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens, such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic, represent major global health challenges. While vaccination is an important part of the arsenal to counter the spread of viral diseases, it presents limitations and needs to be complemented by efficient therapeutic solutions. Intricate knowledge of host-pathogen interactions is a powerful tool to identify host-dependent vulnerabilities that can be exploited to dampen viral replication. Such host-directed antiviral therapies are promising and are less prone to the development of drug-resistant viral strains. Here, we first describe proteomics-based strategies that allow the rapid characterization of host-pathogen interactions. We then discuss how such data can be exploited to help prioritize compounds with potential host-directed antiviral activity that can be tested in preclinical models. äTarget Discovery for Host-Directed Antiviral Therapies: Application of(epmc).pdf DeepDyve Pubget Overpricing