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10.15252/msb.202010079 http://scihub22266oqcxt.onion/10.15252/msb.202010079 34519429!8438690!34519429     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Syst+Biol 2021 ; 17 (9): e10079 Nephropedia Template TP {{tp|p=34519429|t=2021. SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms |pdf=|usr=}}{{34519429}} gab.com Text SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms JO: Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=34519429 #FOAvip We modeled 3D structures of all SARS-CoV-2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that 6% of the proteome mimicked human proteins, while 7% was implicated in hijacking mechanisms that reverse post-translational modifications, block host translation, and disable host defenses; a further 29% self-assembled into heteromeric states that provided insight into how the viral replication and translation complex forms. To make these 3D models more accessible, we devised a structural coverage map, a novel visualization method to show what is-and is not-known about the 3D structure of the viral proteome. We integrated the coverage map into an accompanying online resource (https://aquaria.ws/covid) that can be used to find and explore models corresponding to the 79 structural states identified in this work. The resulting Aquaria-COVID resource helps scientists use emerging structural data to understand the mechanisms underlying coronavirus infection and draws attention to the 31% of the viral proteome that remains structurally unknown or dark. Twit Text FOAVip SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms ????Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=34519429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34519429 #FOAvip English Wikipedia <ref>{{Cite pmid|34519429}}</ref> SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms #MMPMID34519429 O'Donoghue SI; Schafferhans A; Sikta N; Stolte C; Kaur S; Ho BK; Anderson S; Procter JB; Dallago C; Bordin N; Adcock M; Rost B Mol Syst Biol 2021[Sep]; 17 (9): e10079 PMID34519429show ga We modeled 3D structures of all SARS-CoV-2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that 6% of the proteome mimicked human proteins, while 7% was implicated in hijacking mechanisms that reverse post-translational modifications, block host translation, and disable host defenses; a further 29% self-assembled into heteromeric states that provided insight into how the viral replication and translation complex forms. To make these 3D models more accessible, we devised a structural coverage map, a novel visualization method to show what is-and is not-known about the 3D structure of the viral proteome. We integrated the coverage map into an accompanying online resource (https://aquaria.ws/covid) that can be used to find and explore models corresponding to the 79 structural states identified in this work. The resulting Aquaria-COVID resource helps scientists use emerging structural data to understand the mechanisms underlying coronavirus infection and draws attention to the 31% of the viral proteome that remains structurally unknown or dark. |*Protein Processing, Post-Translational[MESH] |Amino Acid Transport Systems, Neutral/chemistry/genetics/metabolism[MESH] |Angiotensin-Converting Enzyme 2/chemistry/genetics/*metabolism[MESH] |Binding Sites[MESH] |COVID-19/genetics/metabolism/virology[MESH] |Computational Biology/methods[MESH] |Coronavirus Envelope Proteins/chemistry/genetics/metabolism[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/genetics/metabolism[MESH] |Host-Pathogen Interactions/*genetics[MESH] |Humans[MESH] |Mitochondrial Membrane Transport Proteins/chemistry/genetics/metabolism[MESH] |Mitochondrial Precursor Protein Import Complex Proteins[MESH] |Models, Molecular[MESH] |Molecular Mimicry[MESH] |Neuropilin-1/chemistry/genetics/metabolism[MESH] |Phosphoproteins/chemistry/genetics/metabolism[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |Protein Interaction Mapping/methods[MESH] |Protein Multimerization[MESH] |SARS-CoV-2/chemistry/genetics/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/*metabolism[MESH] |Viral Matrix Proteins/chemistry/genetics/metabolism[MESH] |Viroporin Proteins/chemistry/genetics/metabolism[MESH]SARS-CoV-2 structural coverage map reveals viral protein assembly, mim(epmc).pdf DeepDyve Pubget Overpricing