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10.1038/s41418-021-00866-0 http://scihub22266oqcxt.onion/10.1038/s41418-021-00866-0 34518653!8435761!34518653     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2022 ; 29 (2): 420-438 Nephropedia Template TP {{tp|p=34518653|t=2022. Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis |pdf=|usr=}}{{34518653}} gab.com Text Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=34518653 #FOAvip Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS), exemplified by key clinical phenotypes unearthed during the SARS-CoV-2 pandemic. The underlying pathophysiology of CRS remains elusive. We found that FLIP, a protein that controls caspase-8 death pathways, was highly expressed in myeloid cells of COVID-19 lungs. FLIP controlled CRS by fueling a STAT3-dependent inflammatory program. Indeed, constitutive expression of a viral FLIP homolog in myeloid cells triggered a STAT3-linked, progressive, and fatal inflammatory syndrome in mice, characterized by elevated cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions that mimicked human CRS. As STAT3-targeting approaches relieved inflammation, immune disorders, and organ failures in these mice, targeted intervention towards this pathway could suppress the lethal CRS inflammatory state. Twit Text FOAVip Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=34518653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34518653 #FOAvip English Wikipedia <ref>{{Cite pmid|34518653}}</ref> Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis #MMPMID34518653 Musiu C; Caligola S; Fiore A; Lamolinara A; Frusteri C; Del Pizzo FD; De Sanctis F; Cane S; Adamo A; Hofer F; Barouni RM; Grilli A; Zilio S; Serafini P; Tacconelli E; Donadello K; Gottin L; Polati E; Girelli D; Polidoro I; Iezzi PA; Angelucci D; Capece A; Chen Y; Shi ZL; Murray PJ; Chilosi M; Amit I; Bicciato S; Iezzi M; Bronte V; Ugel S Cell Death Differ 2022[Feb]; 29 (2): 420-438 PMID34518653show ga Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS), exemplified by key clinical phenotypes unearthed during the SARS-CoV-2 pandemic. The underlying pathophysiology of CRS remains elusive. We found that FLIP, a protein that controls caspase-8 death pathways, was highly expressed in myeloid cells of COVID-19 lungs. FLIP controlled CRS by fueling a STAT3-dependent inflammatory program. Indeed, constitutive expression of a viral FLIP homolog in myeloid cells triggered a STAT3-linked, progressive, and fatal inflammatory syndrome in mice, characterized by elevated cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions that mimicked human CRS. As STAT3-targeting approaches relieved inflammation, immune disorders, and organ failures in these mice, targeted intervention towards this pathway could suppress the lethal CRS inflammatory state. |Aged[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |COVID-19/metabolism/*physiopathology[MESH] |Caspase 8/metabolism[MESH] |Cytokine Release Syndrome/*etiology/*metabolism[MESH] |Cytokines/immunology/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH] |STAT3 Transcription Factor/genetics/*metabolism[MESH]Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis (epmc).pdf DeepDyve Pubget Overpricing