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10.1016/j.ijbiomac.2021.09.018 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.09.018 34517025!8431879!34517025     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 190 (ä): 636-648 Nephropedia Template TP {{tp|p=34517025|t=2021. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation |pdf=|usr=}}{{34517025}} gab.com Text Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=34517025 #FOAvip SARS-CoV-2 nucleocapsid (N) protein undergoes RNA-induced phase separation (LLPS) and sequesters the host key stress granule (SG) proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and 2 (G3BP1 and G3BP2) to inhibit SG formation. This will allow viral packaging and propagation in host cells. Based on a genomic-guided meta-analysis, here we identify upstream regulatory elements modulating the expression of G3BP1 and G3BP2 (collectively called G3BP1/2). Using this strategy, we have identified FOXA1, YY1, SYK, E2F-1, and TGFBR2 as activators and SIN3A, SRF, and AKT-1 as repressors of G3BP1/2 genes. Panels of the activators and repressors were then used to identify drugs that change their gene expression signatures. Two drugs, imatinib, and decitabine have been identified as putative modulators of G3BP1/2 genes and their regulators, suggesting their role as COVID-19 mitigation agents. Molecular docking analysis suggests that both drugs bind to G3BP1/2 with a much higher affinity than the SARS-CoV-2 N protein. This study reports imatinib and decitabine as candidate drugs against N protein and G3BP1/2 protein. Twit Text FOAVip Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=34517025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34517025 #FOAvip English Wikipedia <ref>{{Cite pmid|34517025}}</ref> Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation #MMPMID34517025 Ali N; Prasad K; AlAsmari AF; Alharbi M; Rashid S; Kumar V Int J Biol Macromol 2021[Nov]; 190 (ä): 636-648 PMID34517025show ga SARS-CoV-2 nucleocapsid (N) protein undergoes RNA-induced phase separation (LLPS) and sequesters the host key stress granule (SG) proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and 2 (G3BP1 and G3BP2) to inhibit SG formation. This will allow viral packaging and propagation in host cells. Based on a genomic-guided meta-analysis, here we identify upstream regulatory elements modulating the expression of G3BP1 and G3BP2 (collectively called G3BP1/2). Using this strategy, we have identified FOXA1, YY1, SYK, E2F-1, and TGFBR2 as activators and SIN3A, SRF, and AKT-1 as repressors of G3BP1/2 genes. Panels of the activators and repressors were then used to identify drugs that change their gene expression signatures. Two drugs, imatinib, and decitabine have been identified as putative modulators of G3BP1/2 genes and their regulators, suggesting their role as COVID-19 mitigation agents. Molecular docking analysis suggests that both drugs bind to G3BP1/2 with a much higher affinity than the SARS-CoV-2 N protein. This study reports imatinib and decitabine as candidate drugs against N protein and G3BP1/2 protein. |*COVID-19 Drug Treatment[MESH] |*Molecular Docking Simulation[MESH] |*Molecular Dynamics Simulation[MESH] |Adaptor Proteins, Signal Transducing/antagonists & inhibitors/*chemistry/metabolism[MESH] |COVID-19/metabolism[MESH] |Coronavirus Nucleocapsid Proteins/*chemistry/metabolism[MESH] |DNA Helicases/antagonists & inhibitors/*chemistry/metabolism[MESH] |Decitabine/*chemistry/pharmacology[MESH] |Drug Delivery Systems[MESH] |Genomics[MESH] |Imatinib Mesylate/*chemistry/pharmacology[MESH] |Phosphoproteins/chemistry/metabolism[MESH] |Poly-ADP-Ribose Binding Proteins/antagonists & inhibitors/*chemistry/metabolism[MESH] |RNA Helicases/antagonists & inhibitors/*chemistry/metabolism[MESH] |RNA Recognition Motif Proteins/antagonists & inhibitors/*chemistry/metabolism[MESH] |RNA-Binding Proteins/antagonists & inhibitors/*chemistry/metabolism[MESH]Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibi(epmc).pdf DeepDyve Pubget Overpricing