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10.1016/j.cbi.2021.109657 http://scihub22266oqcxt.onion/10.1016/j.cbi.2021.109657 34516971!8432980!34516971     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Interact 2021 ; 348 (ä): 109657 Nephropedia Template TP {{tp|p=34516971|t=2021. Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19 |pdf=|usr=}}{{34516971}} gab.com Text Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19 JO: Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=34516971 #FOAvip COVID-19 is an ongoing public health emergency that has affected millions of people worldwide and is still a threat to many more. One of the pathophysiological features of COVID-19 is associated with the activation of vascular endothelial cells (ECs) leading to the disruption of vascular integrity, coagulation and inflammation. An interlink mechanism between coagulation and inflammatory pathways has been reported in COVID-19. Multiple components are involved in these pathological pathways. Out of all, Von Willebrand Factor (VWF) is one of the primary components of coagulation pathway and also a mediator of vascular inflammation that plays an important role in thrombo-inflammation that further leads to acute respiratory distress syndrome (ARDS). The thrombo-inflammatory co-morbidities such as hyper-coagulation, thrombosis, ARDS etc. have become the major cause of mortality in the patients of COVID-19 admitted to the ICU. Thus, VWF can be explored as a potential target to manage COVID-19 associated co-morbidities. Supporting this hypothesis, there are literature reports which disclose previous attempts to target VWF for the management of thrombo-inflammation in other pathological conditions. The current report summarizes emerging insights into the pathophysiology, mechanism(s), diagnosis, management and foundations for research on this less explored clinically relevant glycoprotein as coagulation biomarker in COVID-19. Twit Text FOAVip Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19 ????Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=34516971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34516971 #FOAvip English Wikipedia <ref>{{Cite pmid|34516971}}</ref> Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19 #MMPMID34516971 Choudhary S; Sharma K; Singh PK Chem Biol Interact 2021[Oct]; 348 (ä): 109657 PMID34516971show ga COVID-19 is an ongoing public health emergency that has affected millions of people worldwide and is still a threat to many more. One of the pathophysiological features of COVID-19 is associated with the activation of vascular endothelial cells (ECs) leading to the disruption of vascular integrity, coagulation and inflammation. An interlink mechanism between coagulation and inflammatory pathways has been reported in COVID-19. Multiple components are involved in these pathological pathways. Out of all, Von Willebrand Factor (VWF) is one of the primary components of coagulation pathway and also a mediator of vascular inflammation that plays an important role in thrombo-inflammation that further leads to acute respiratory distress syndrome (ARDS). The thrombo-inflammatory co-morbidities such as hyper-coagulation, thrombosis, ARDS etc. have become the major cause of mortality in the patients of COVID-19 admitted to the ICU. Thus, VWF can be explored as a potential target to manage COVID-19 associated co-morbidities. Supporting this hypothesis, there are literature reports which disclose previous attempts to target VWF for the management of thrombo-inflammation in other pathological conditions. The current report summarizes emerging insights into the pathophysiology, mechanism(s), diagnosis, management and foundations for research on this less explored clinically relevant glycoprotein as coagulation biomarker in COVID-19. |Biomarkers/metabolism[MESH] |COVID-19/*complications/metabolism[MESH] |Humans[MESH] |Inflammation/complications[MESH] |Thrombosis/*complications[MESH]Von Willebrand factor: A key glycoprotein involved in thrombo-inflamma(epmc).pdf DeepDyve Pubget Overpricing