Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.15252/embj.2020106765

http://scihub22266oqcxt.onion/10.15252/embj.2020106765
suck pdf from google scholar
34510494!8521309!34510494
unlimited free pdf from europmc34510494    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid34510494      EMBO+J 2021 ; 40 (20): e106765
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans #MMPMID34510494
  • Bermejo-Jambrina M; Eder J; Kaptein TM; van Hamme JL; Helgers LC; Vlaming KE; Brouwer PJM; van Nuenen AC; Spaargaren M; de Bree GJ; Nijmeijer BM; Kootstra NA; van Gils MJ; Sanders RW; Geijtenbeek TBH
  • EMBO J 2021[Oct]; 40 (20): e106765 PMID34510494show ga
  • The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outbreaks of new variants highlight the need for preventive treatments. Here, we identified heparan sulfate proteoglycans as attachment receptors for SARS-CoV-2. Notably, neutralizing antibodies against SARS-CoV-2 isolated from COVID-19 patients interfered with SARS-CoV-2 binding to heparan sulfate proteoglycans, which might be an additional mechanism of antibodies to neutralize infection. SARS-CoV-2 binding to and infection of epithelial cells was blocked by low molecular weight heparins (LMWH). Although dendritic cells (DCs) and mucosal Langerhans cells (LCs) were not infected by SARS-CoV-2, both DC subsets efficiently captured SARS-CoV-2 via heparan sulfate proteoglycans and transmitted the virus to ACE2-positive cells. Notably, human primary nasal cells were infected by SARS-CoV-2, and infection was blocked by pre-treatment with LMWH. These data strongly suggest that heparan sulfate proteoglycans are important attachment receptors facilitating infection and transmission, and support the use of LMWH as prophylaxis against SARS-CoV-2 infection.
  • |Angiotensin-Converting Enzyme 2/immunology/metabolism[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/metabolism/pharmacology[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*transmission[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Dendritic Cells/metabolism/virology[MESH]
  • |Epithelial Cells/metabolism/virology[MESH]
  • |Heparan Sulfate Proteoglycans/*metabolism[MESH]
  • |Heparin, Low-Molecular-Weight/*pharmacology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Mucous Membrane/cytology/virology[MESH]
  • |SARS-CoV-2/metabolism/*pathogenicity[MESH]
  • |Syndecan-1/metabolism[MESH]
  • |Syndecan-4/metabolism[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box