Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.2020106765 http://scihub22266oqcxt.onion/10.15252/embj.2020106765 34510494!8521309!34510494     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34510494&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34510494.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2021 ; 40 (20): e106765 Nephropedia Template TP {{tp|p=34510494|t=2021. Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans |pdf=|usr=}}{{34510494}} gab.com Text Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=34510494 #FOAvip The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outbreaks of new variants highlight the need for preventive treatments. Here, we identified heparan sulfate proteoglycans as attachment receptors for SARS-CoV-2. Notably, neutralizing antibodies against SARS-CoV-2 isolated from COVID-19 patients interfered with SARS-CoV-2 binding to heparan sulfate proteoglycans, which might be an additional mechanism of antibodies to neutralize infection. SARS-CoV-2 binding to and infection of epithelial cells was blocked by low molecular weight heparins (LMWH). Although dendritic cells (DCs) and mucosal Langerhans cells (LCs) were not infected by SARS-CoV-2, both DC subsets efficiently captured SARS-CoV-2 via heparan sulfate proteoglycans and transmitted the virus to ACE2-positive cells. Notably, human primary nasal cells were infected by SARS-CoV-2, and infection was blocked by pre-treatment with LMWH. These data strongly suggest that heparan sulfate proteoglycans are important attachment receptors facilitating infection and transmission, and support the use of LMWH as prophylaxis against SARS-CoV-2 infection. Twit Text FOAVip Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=34510494 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34510494 #FOAvip English Wikipedia <ref>{{Cite pmid|34510494}}</ref> Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans #MMPMID34510494 Bermejo-Jambrina M; Eder J; Kaptein TM; van Hamme JL; Helgers LC; Vlaming KE; Brouwer PJM; van Nuenen AC; Spaargaren M; de Bree GJ; Nijmeijer BM; Kootstra NA; van Gils MJ; Sanders RW; Geijtenbeek TBH EMBO J 2021[Oct]; 40 (20): e106765 PMID34510494show ga The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outbreaks of new variants highlight the need for preventive treatments. Here, we identified heparan sulfate proteoglycans as attachment receptors for SARS-CoV-2. Notably, neutralizing antibodies against SARS-CoV-2 isolated from COVID-19 patients interfered with SARS-CoV-2 binding to heparan sulfate proteoglycans, which might be an additional mechanism of antibodies to neutralize infection. SARS-CoV-2 binding to and infection of epithelial cells was blocked by low molecular weight heparins (LMWH). Although dendritic cells (DCs) and mucosal Langerhans cells (LCs) were not infected by SARS-CoV-2, both DC subsets efficiently captured SARS-CoV-2 via heparan sulfate proteoglycans and transmitted the virus to ACE2-positive cells. Notably, human primary nasal cells were infected by SARS-CoV-2, and infection was blocked by pre-treatment with LMWH. These data strongly suggest that heparan sulfate proteoglycans are important attachment receptors facilitating infection and transmission, and support the use of LMWH as prophylaxis against SARS-CoV-2 infection. |Angiotensin-Converting Enzyme 2/immunology/metabolism[MESH] |Animals[MESH] |Antibodies, Neutralizing/metabolism/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*transmission[MESH] |Chlorocebus aethiops[MESH] |Dendritic Cells/metabolism/virology[MESH] |Epithelial Cells/metabolism/virology[MESH] |Heparan Sulfate Proteoglycans/*metabolism[MESH] |Heparin, Low-Molecular-Weight/*pharmacology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Mucous Membrane/cytology/virology[MESH] |SARS-CoV-2/metabolism/*pathogenicity[MESH] |Syndecan-1/metabolism[MESH] |Syndecan-4/metabolism[MESH]Infection and transmission of SARS-CoV-2 depend on heparan sulfate pro(epmc).pdf DeepDyve Pubget Overpricing