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10.1038/s41598-021-97658-w

http://scihub22266oqcxt.onion/10.1038/s41598-021-97658-w
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34508172!8433326!34508172
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suck abstract from ncbi


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pmid34508172      Sci+Rep 2021 ; 11 (1): 18085
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  • Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro #MMPMID34508172
  • Murray J; Hogan RJ; Martin DE; Blahunka K; Sancilio FD; Balyan R; Lovern M; Still R; Tripp RA
  • Sci Rep 2021[Sep]; 11 (1): 18085 PMID34508172show ga
  • Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC(90) value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Epithelial Cells/*drug effects/virology[MESH]
  • |Humans[MESH]
  • |Lung/*drug effects/virology[MESH]
  • |Probenecid/*pharmacology[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Vero Cells[MESH]


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