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10.1016/j.envint.2021.106862

http://scihub22266oqcxt.onion/10.1016/j.envint.2021.106862
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suck abstract from ncbi


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pmid34507232      Environ+Int 2021 ; 157 (ä): 106862
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  • Near-roadway air pollution associated with COVID-19 severity and mortality - Multiethnic cohort study in Southern California #MMPMID34507232
  • Chen Z; Huang BZ; Sidell MA; Chow T; Eckel SP; Pavlovic N; Martinez MP; Lurmann F; Thomas DC; Gilliland FD; Xiang AH
  • Environ Int 2021[Dec]; 157 (ä): 106862 PMID34507232show ga
  • BACKGROUND: Air pollution exposure has been associated with increased risk of COVID-19 incidence and mortality by ecological analyses. Few studies have investigated the specific effect of traffic-related air pollution on COVID-19 severity. OBJECTIVE: To investigate the associations of near-roadway air pollution (NRAP) exposure with COVID-19 severity and mortality using individual-level exposure and outcome data. METHODS: The retrospective cohort includes 75,010 individuals (mean age 42.5 years, 54% female, 66% Hispanic) diagnosed with COVID-19 at Kaiser Permanente Southern California between 3/1/2020-8/31/2020. NRAP exposures from both freeways and non-freeways during 1-year prior to the COVID-19 diagnosis date were estimated based on residential address history using the CALINE4 line source dispersion model. Primary outcomes include COVID-19 severity defined as COVID-19-related hospitalizations, intensive respiratory support (IRS), intensive care unit (ICU) admissions within 30 days, and mortality within 60 days after COVID-19 diagnosis. Covariates including socio-characteristics and comorbidities were adjusted for in the analysis. RESULT: One standard deviation (SD) increase in 1-year-averaged non-freeway NRAP (0.5 ppb NO(x)) was associated with increased odds of COVID-19-related IRS and ICU admission [OR (95% CI): 1.07 (1.01, 1.13) and 1.11 (1.04, 1.19) respectively] and increased risk of mortality (HR = 1.10, 95% CI = 1.03, 1.18). The associations of non-freeway NRAP with COVID-19 outcomes were largely independent of the effect of regional fine particulate matter and nitrogen dioxide exposures. These associations were generally consistent across age, sex, and race/ethnicity subgroups. The associations of freeway and total NRAP with COVID-19 severity and mortality were not statistically significant. CONCLUSIONS: Data from this multiethnic cohort suggested that NRAP, particularly non-freeway exposure in Southern California, may be associated with increased risk of COVID-19 severity and mortality among COVID-19 infected patients. Future studies are needed to assess the impact of emerging COVID-19 variants and chemical components from freeway and non-freeway NRAP.
  • |*Air Pollutants/analysis/toxicity[MESH]
  • |*Air Pollution/adverse effects/analysis[MESH]
  • |*COVID-19[MESH]
  • |Adult[MESH]
  • |COVID-19 Testing[MESH]
  • |California/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Environmental Exposure/adverse effects/analysis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Retrospective Studies[MESH]


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