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10.2174/1871530321666210909165757 http://scihub22266oqcxt.onion/10.2174/1871530321666210909165757 34503433!?!34503433 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34503433&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Endocr+Metab+Immune+Disord+Drug+Targets 2022 ; 22 (12): 1149-1153 Nephropedia Template TP {{tp|p=34503433|t=2022. Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective |pdf=|usr=}}{{34503433}} gab.com Text Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective JO: Endocr Metab Immune Disord Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=34503433 #FOAvip Coronavirus disease-19 (COVID-19) can be a fatal disease and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). SARS-CoV2 is an enveloped virus that belongs to the Beta coronavirus subfamily. After entering into the target cells, this virus replicates rapidly and leads to cellular damage and uncontrolled pulmonary inflammation. Huge amounts of inflammatory cytokines and chemokines are produced by infected lung cells and are associated with monocyte recruitment and accumulation of inflammatory macrophages at the site of infection. Mitochondrial citrate carrier (CIC) expression increases in these macrophages, which results in elevated levels of cytosolic citrate and the production of inflammatory mediators. In this perspective article, we discuss the role of mitochondrial CIC in the metabolism of inflammatory macrophages and we propose that inhibition of this carrier might be a novel therapeutic approach for COVID-19 patients. Twit Text FOAVip Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective ????Endocr Metab Immune Disord Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=34503433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34503433 #FOAvip English Wikipedia <ref>{{Cite pmid|34503433}}</ref> Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective #MMPMID34503433 Vakili ME; Saleh Z; Kabelitz D; Kalantar K Endocr Metab Immune Disord Drug Targets 2022[]; 22 (12): 1149-1153 PMID34503433show ga Coronavirus disease-19 (COVID-19) can be a fatal disease and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). SARS-CoV2 is an enveloped virus that belongs to the Beta coronavirus subfamily. After entering into the target cells, this virus replicates rapidly and leads to cellular damage and uncontrolled pulmonary inflammation. Huge amounts of inflammatory cytokines and chemokines are produced by infected lung cells and are associated with monocyte recruitment and accumulation of inflammatory macrophages at the site of infection. Mitochondrial citrate carrier (CIC) expression increases in these macrophages, which results in elevated levels of cytosolic citrate and the production of inflammatory mediators. In this perspective article, we discuss the role of mitochondrial CIC in the metabolism of inflammatory macrophages and we propose that inhibition of this carrier might be a novel therapeutic approach for COVID-19 patients. |*COVID-19 Drug Treatment[MESH] |Chemokines[MESH] |Citrates[MESH] |Cytokines[MESH] |Humans[MESH] |Macrophages[MESH] |RNA, Viral[MESH]Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel(epmc).pdf DeepDyve Pubget Overpricing