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10.3390/ijms22179228 http://scihub22266oqcxt.onion/10.3390/ijms22179228 34502134!8431536!34502134     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (17): ä Nephropedia Template TP {{tp|p=34502134|t=2021. SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues |pdf=|usr=}}{{34502134}} gab.com Text SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34502134 #FOAvip The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of COVID-19 patients and healthy controls. In COVID-19 patients, DC-SIGN gene expression was interestingly decreased in lung DCs but increased in blood DCs. Within DCs, conventional DCs (cDCs) were depleted while plasmacytoid DCs (pDCs) were augmented in the lungs of mild COVID-19. In severe cases, we identified augmented types of immature DCs (CD22(+) or ANXA1(+) DCs) with MHCII downregulation. In this study, our observation indicates that DCs in severe cases stimulate innate immune responses but fail to specifically present SARS-CoV-2. It provides insights into the profound modulation of DC function in severe COVID-19. Twit Text FOAVip SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34502134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34502134 #FOAvip English Wikipedia <ref>{{Cite pmid|34502134}}</ref> SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues #MMPMID34502134 Cai G; Du M; Bosse Y; Albrecht H; Qin F; Luo X; Androulakis XM; Cheng C; Nagarkatti M; Nagarkatti P; Christiani DC; Whitfield ML; Amos CI; Xiao F Int J Mol Sci 2021[Aug]; 22 (17): ä PMID34502134show ga The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of COVID-19 patients and healthy controls. In COVID-19 patients, DC-SIGN gene expression was interestingly decreased in lung DCs but increased in blood DCs. Within DCs, conventional DCs (cDCs) were depleted while plasmacytoid DCs (pDCs) were augmented in the lungs of mild COVID-19. In severe cases, we identified augmented types of immature DCs (CD22(+) or ANXA1(+) DCs) with MHCII downregulation. In this study, our observation indicates that DCs in severe cases stimulate innate immune responses but fail to specifically present SARS-CoV-2. It provides insights into the profound modulation of DC function in severe COVID-19. |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |COVID-19/diagnosis/*immunology/pathology/virology[MESH] |Cell Adhesion Molecules/*genetics/metabolism[MESH] |Datasets as Topic[MESH] |Dendritic Cells/*immunology/metabolism[MESH] |Gene Expression Regulation/*immunology[MESH] |Genome-Wide Association Study[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Lectins, C-Type/*genetics/metabolism[MESH] |Lung/immunology/pathology/virology[MESH] |Mendelian Randomization Analysis[MESH] |Nasopharynx/immunology/pathology/virology[MESH] |RNA-Seq[MESH] |Receptors, Cell Surface/*genetics/metabolism[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expressi(epmc).pdf DeepDyve Pubget Overpricing