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10.3390/jcm10174019 http://scihub22266oqcxt.onion/10.3390/jcm10174019 34501467!8432474!34501467     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Med 2021 ; 10 (17): ä Nephropedia Template TP {{tp|p=34501467|t=2021. Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19 |pdf=|usr=}}{{34501467}} gab.com Text Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19 JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=34501467 #FOAvip BACKGROUND: Immunomodulatory drugs have been used in patients with severe COVID-19. The objective of this study was to evaluate the effects of two different strategies, based either on an interleukin-1 inhibitor, anakinra, or on a JAK inhibitor, such as baricitinib, on the survival of patients hospitalized with COVID-19 pneumonia. METHODS: Individuals admitted to two hospitals because of COVID-19 were included if they fulfilled the clinical, radiological, and laboratory criteria for moderate-to-severe disease. Patients were classified according to the first immunomodulatory drug prescribed: anakinra or baricitinib. All subjects were concomitantly treated with corticosteroids, in addition to standard care. The main outcomes were the need for invasive mechanical ventilation (IMV) and in-hospital death. Statistical analysis included propensity score matching and Cox regression model. RESULTS: The study subjects included 125 and 217 individuals in the anakinra and baricitinib groups, respectively. IMV was required in 13 (10.4%) and 10 (4.6%) patients, respectively (p = 0.039). During this period, 22 (17.6%) and 36 (16.6%) individuals died in both groups (p = 0.811). Older age, low functional status, high comorbidity, need for IMV, elevated lactate dehydrogenase, and use of a high flow of oxygen at initially were found to be associated with worse clinical outcomes. No differences according to the immunomodulatory therapy used were observed. For most of the deceased individuals, early interruption of anakinra or baricitinib had occurred at the time of their admission to the intensive care unit. CONCLUSIONS: Similar mortality is observed in patients treated with anakinra or baricitinib plus corticosteroids. Twit Text FOAVip Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19 ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=34501467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34501467 #FOAvip English Wikipedia <ref>{{Cite pmid|34501467}}</ref> Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19 #MMPMID34501467 Garcia-Garcia JA; Perez-Quintana M; Ramos-Giraldez C; Cebrian-Gonzalez I; Martin-Ponce ML; Del Valle-Villagran J; Navarro-Puerto MA; Sanchez-Villegas J; Gomez-Herreros R; Manoja-Bustos I; Leon-Marti D; Serrano-Rodriguez L; de Miguel-Albarreal A; Velasco-Romero MJ; Mula-Falcon F; Fernandez-Perez P; Melguizo-Moya I; Perez-Quintana MJ; Romero-Molina G; Vergara-Lopez S; Marenco-de la Fuente JL; Marin-Martin J; Mira-Escarti JA J Clin Med 2021[Sep]; 10 (17): ä PMID34501467show ga BACKGROUND: Immunomodulatory drugs have been used in patients with severe COVID-19. The objective of this study was to evaluate the effects of two different strategies, based either on an interleukin-1 inhibitor, anakinra, or on a JAK inhibitor, such as baricitinib, on the survival of patients hospitalized with COVID-19 pneumonia. METHODS: Individuals admitted to two hospitals because of COVID-19 were included if they fulfilled the clinical, radiological, and laboratory criteria for moderate-to-severe disease. Patients were classified according to the first immunomodulatory drug prescribed: anakinra or baricitinib. All subjects were concomitantly treated with corticosteroids, in addition to standard care. The main outcomes were the need for invasive mechanical ventilation (IMV) and in-hospital death. Statistical analysis included propensity score matching and Cox regression model. RESULTS: The study subjects included 125 and 217 individuals in the anakinra and baricitinib groups, respectively. IMV was required in 13 (10.4%) and 10 (4.6%) patients, respectively (p = 0.039). During this period, 22 (17.6%) and 36 (16.6%) individuals died in both groups (p = 0.811). Older age, low functional status, high comorbidity, need for IMV, elevated lactate dehydrogenase, and use of a high flow of oxygen at initially were found to be associated with worse clinical outcomes. No differences according to the immunomodulatory therapy used were observed. For most of the deceased individuals, early interruption of anakinra or baricitinib had occurred at the time of their admission to the intensive care unit. CONCLUSIONS: Similar mortality is observed in patients treated with anakinra or baricitinib plus corticosteroids. äAnakinra versus Baricitinib: Different Strategies for Patients Hospita(epmc).pdf DeepDyve Pubget Overpricing