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10.1016/j.compbiolchem.2021.107570 http://scihub22266oqcxt.onion/10.1016/j.compbiolchem.2021.107570 34500325!8410225!34500325     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Biol+Chem 2021 ; 94 (ä): 107570 Nephropedia Template TP {{tp|p=34500325|t=2021. Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy |pdf=|usr=}}{{34500325}} gab.com Text Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy JO: Comput Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=34500325 #FOAvip The base order-dependent component of folding energy has revealed a highly conserved region in HIV-1 genomes that associates with RNA structure. This corresponds to a packaging signal that is recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achilles heel," the signal can be targeted by a new antiviral compound. Although SARS-CoV-2 differs in many respects from HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. This indicates structural invariance (SI) sustained by natural selection. While the regions are often also protein-encoding (e. g. NSP3, ORF3a), we suggest that their nucleic acid level functions can be considered potential "Achilles heels" for SARS-CoV-2, perhaps susceptible to therapies like those envisaged for AIDS. The ribosomal frameshifting element scored well, but higher SI scores were obtained in other regions, including those encoding NSP13 and the nucleocapsid (N) protein. Twit Text FOAVip Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy ????Comput Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=34500325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34500325 #FOAvip English Wikipedia <ref>{{Cite pmid|34500325}}</ref> Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy #MMPMID34500325 Zhang C; Forsdyke DR Comput Biol Chem 2021[Oct]; 94 (ä): 107570 PMID34500325show ga The base order-dependent component of folding energy has revealed a highly conserved region in HIV-1 genomes that associates with RNA structure. This corresponds to a packaging signal that is recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achilles heel," the signal can be targeted by a new antiviral compound. Although SARS-CoV-2 differs in many respects from HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. This indicates structural invariance (SI) sustained by natural selection. While the regions are often also protein-encoding (e. g. NSP3, ORF3a), we suggest that their nucleic acid level functions can be considered potential "Achilles heels" for SARS-CoV-2, perhaps susceptible to therapies like those envisaged for AIDS. The ribosomal frameshifting element scored well, but higher SI scores were obtained in other regions, including those encoding NSP13 and the nucleocapsid (N) protein. |*RNA Folding[MESH] |Base Sequence[MESH] |COVID-19/*virology[MESH] |Genome, Viral[MESH] |RNA, Viral/*chemistry/genetics/metabolism[MESH]Potential Achilles heels of SARS-CoV-2 are best displayed by the base (epmc).pdf DeepDyve Pubget Overpricing