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10.1016/j.cell.2021.08.016 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.08.016 34492226!8373821!34492226     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (19): 4953-4968.e16 Nephropedia Template TP {{tp|p=34492226|t=2021. The interferon landscape along the respiratory tract impacts the severity of COVID-19 |pdf=|usr=}}{{34492226}} gab.com Text The interferon landscape along the respiratory tract impacts the severity of COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34492226 #FOAvip Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites. Twit Text FOAVip The interferon landscape along the respiratory tract impacts the severity of COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34492226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34492226 #FOAvip English Wikipedia <ref>{{Cite pmid|34492226}}</ref> The interferon landscape along the respiratory tract impacts the severity of COVID-19 #MMPMID34492226 Sposito B; Broggi A; Pandolfi L; Crotta S; Clementi N; Ferrarese R; Sisti S; Criscuolo E; Spreafico R; Long JM; Ambrosi A; Liu E; Frangipane V; Saracino L; Bozzini S; Marongiu L; Facchini FA; Bottazzi A; Fossali T; Colombo R; Clementi M; Tagliabue E; Chou J; Pontiroli AE; Meloni F; Wack A; Mancini N; Zanoni I Cell 2021[Sep]; 184 (19): 4953-4968.e16 PMID34492226show ga Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites. |*Severity of Illness Index[MESH] |Age Factors[MESH] |Aging/pathology[MESH] |COVID-19/genetics/immunology/*pathology[MESH] |Epithelial Cells/pathology/virology[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Interferons/genetics/*metabolism[MESH] |Leukocytes/pathology/virology[MESH] |Lung/pathology/virology[MESH] |Respiratory Distress Syndrome/pathology/virology[MESH] |Respiratory System/*virology[MESH]The interferon landscape along the respiratory tract impacts the sever(epmc).pdf DeepDyve Pubget Overpricing