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10.3389/fmed.2021.637885 http://scihub22266oqcxt.onion/10.3389/fmed.2021.637885 34490283!8417536!34490283     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34490283&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Med+(Lausanne) 2021 ; 8 (?): 637885 Nephropedia Template TP {{tp|p=34490283|t=2021. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19 |pdf=|usr=}}{{34490283}} gab.com Text Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19 JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34490283 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2. Here, we showed that patients with Barrett's esophagus (BE) have a higher expression of ACE2 in BE tissues compared to normal squamous esophagus, and that the lower pH associated with BE may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased ACE2 expression and higher viral load upon SARS-CoV-2 infection. We also showed in two independent cohorts of 1,357 COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection and COVID-19 severity. Twit Text FOAVip Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19 ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34490283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34490283 #FOAvip English Wikipedia <ref>{{Cite pmid|34490283}}</ref> Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19 #MMPMID34490283 Jimenez L; Campos Codo A; Sampaio VS; Oliveira AER; Ferreira LKK; Davanzo GG; de Brito Monteiro L; Victor Virgilio-da-Silva J; Borba MGS; Fabiano de Souza G; Zini N; de Andrade Gandolfi F; Muraro SP; Luiz Proenca-Modena J; Val FA; Cardoso Melo G; Monteiro WM; Nogueira ML; Lacerda MVG; Moraes-Vieira PM; Nakaya HI Front Med (Lausanne) 2021[]; 8 (?): 637885 PMID34490283show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2. Here, we showed that patients with Barrett's esophagus (BE) have a higher expression of ACE2 in BE tissues compared to normal squamous esophagus, and that the lower pH associated with BE may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased ACE2 expression and higher viral load upon SARS-CoV-2 infection. We also showed in two independent cohorts of 1,357 COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection and COVID-19 severity. ?Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-(epmc).pdf DeepDyve Pubget Overpricing