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10.1038/s41587-021-01020-4 http://scihub22266oqcxt.onion/10.1038/s41587-021-01020-4 34489601!9206886!34489601     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2022 ; 40 (1): 110-120 Nephropedia Template TP {{tp|p=34489601|t=2022. Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 |pdf=|usr=}}{{34489601}} gab.com Text Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34489601 #FOAvip A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival. Twit Text FOAVip Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34489601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34489601 #FOAvip English Wikipedia <ref>{{Cite pmid|34489601}}</ref> Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 #MMPMID34489601 Lee JW; Su Y; Baloni P; Chen D; Pavlovitch-Bedzyk AJ; Yuan D; Duvvuri VR; Ng RH; Choi J; Xie J; Zhang R; Murray K; Kornilov S; Smith B; Magis AT; Hoon DSB; Hadlock JJ; Goldman JD; Price ND; Gottardo R; Davis MM; Hood L; Greenberg PD; Heath JR Nat Biotechnol 2022[Jan]; 40 (1): 110-120 PMID34489601show ga A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival. |*Single-Cell Analysis[MESH] |COVID-19/*blood/diagnosis/*immunology/metabolism[MESH] |Humans[MESH] |Monocytes/*metabolism[MESH] |Prognosis[MESH]Integrated analysis of plasma and single immune cells uncovers metabol(epmc).pdf DeepDyve Pubget Overpricing