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10.1186/s40779-021-00340-5 http://scihub22266oqcxt.onion/10.1186/s40779-021-00340-5 34488908!8421188!34488908     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mil+Med+Res 2021 ; 8 (1): 49 Nephropedia Template TP {{tp|p=34488908|t=2021. Differential roles of RIG-I like receptors in SARS-CoV-2 infection |pdf=|usr=}}{{34488908}} gab.com Text Differential roles of RIG-I like receptors in SARS-CoV-2 infection JO: Mil Med Res http://www.kidney.de/pget.php?&tw=1&pmid=34488908 #FOAvip Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5(-/-) and MAVS(-/-), but not in RIG-I(-/-), when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was ~ 2.5-fold higher in RIG-I(-/-) than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells. Twit Text FOAVip Differential roles of RIG-I like receptors in SARS-CoV-2 infection ????Mil Med Res http://www.kidney.de/pget.php?&tw=1&pmid=34488908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34488908 #FOAvip English Wikipedia <ref>{{Cite pmid|34488908}}</ref> Differential roles of RIG-I like receptors in SARS-CoV-2 infection #MMPMID34488908 Yang DM; Geng TT; Harrison AG; Wang PH Mil Med Res 2021[Sep]; 8 (1): 49 PMID34488908show ga Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5(-/-) and MAVS(-/-), but not in RIG-I(-/-), when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was ~ 2.5-fold higher in RIG-I(-/-) than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells. |Adaptor Proteins, Signal Transducing/genetics/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*immunology[MESH] |Cell Line[MESH] |DEAD Box Protein 58/genetics/*metabolism[MESH] |Humans[MESH] |Interferon Lambda[MESH] |Interferon Type I/metabolism[MESH] |Interferon-Induced Helicase, IFIH1/genetics/*metabolism[MESH] |Interferons/metabolism[MESH] |Receptors, Immunologic/genetics/*metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Signal Transduction[MESH]Differential roles of RIG-I like receptors in SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing