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10.2174/1874467214666210906125959

http://scihub22266oqcxt.onion/10.2174/1874467214666210906125959
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34488601!ä!34488601

suck abstract from ncbi


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pmid34488601      Curr+Mol+Pharmacol 2022 ; 15 (2): 418-433
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  • Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics #MMPMID34488601
  • Selvaraj C; Dinesh DC; Krafcikova P; Boura E; Aarthy M; Pravin MA; Singh SK
  • Curr Mol Pharmacol 2022[]; 15 (2): 418-433 PMID34488601show ga
  • The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV- 2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dysfunctions. Recently, the first few vaccines were approved by World Health Organization (WHO) and can eventually save millions of lives. Even though, few drugs are used in emergency like Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism are potential therapeutic targets. This perspective review provides the molecular overview of SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology, and pathogenesis.
  • |*COVID-19 Drug Treatment[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antiviral Agents/chemistry/pharmacology/therapeutic use[MESH]
  • |Catalytic Domain[MESH]
  • |Communicable Disease Control[MESH]


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