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10.1152/physiol.00010.2021

http://scihub22266oqcxt.onion/10.1152/physiol.00010.2021
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34486395!8742736!34486395
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suck abstract from ncbi


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pmid34486395      Physiology+(Bethesda) 2022 ; 37 (1): 46-52
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  • Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients #MMPMID34486395
  • Halpin-Veszeleiova K; Hatfield SM
  • Physiology (Bethesda) 2022[Jan]; 37 (1): 46-52 PMID34486395show ga
  • The hypoxia-hypoxia-inducible factor (HIF)-1alpha-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.
  • |*COVID-19[MESH]
  • |*Neoplasms[MESH]
  • |Humans[MESH]
  • |Hypoxia[MESH]
  • |Receptor, Adenosine A2A[MESH]


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