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10.1038/s41598-021-96875-7 http://scihub22266oqcxt.onion/10.1038/s41598-021-96875-7 34471195!8410838!34471195     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 17473 Nephropedia Template TP {{tp|p=34471195|t=2021. A virus-free cellular model recapitulates several features of severe COVID-19 |pdf=|usr=}}{{34471195}} gab.com Text A virus-free cellular model recapitulates several features of severe COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34471195 #FOAvip As for all newly-emergent pathogens, SARS-CoV-2 presents with a relative paucity of clinical information and experimental models, a situation hampering both the development of new effective treatments and the prediction of future outbreaks. Here, we find that a simple virus-free model, based on publicly available transcriptional data from human cell lines, is surprisingly able to recapitulate several features of the clinically relevant infections. By segregating cell lines (n = 1305) from the CCLE project on the base of their sole angiotensin-converting enzyme 2 (ACE2) mRNA content, we found that overexpressing cells present with molecular features resembling those of at-risk patients, including senescence, impairment of antibody production, epigenetic regulation, DNA repair and apoptosis, neutralization of the interferon response, proneness to an overemphasized innate immune activity, hyperinflammation by IL-1, diabetes, hypercoagulation and hypogonadism. Likewise, several pathways were found to display a differential expression between sexes, with males being in the least advantageous position, thus suggesting that the model could reproduce even the sex-related disparities observed in the clinical outcome of patients with COVID-19. Overall, besides validating a new disease model, our data suggest that, in patients with severe COVID-19, a baseline ground could be already present and, as a consequence, the viral infection might simply exacerbate a variety of latent (or inherent) pre-existing conditions, representing therefore a tipping point at which they become clinically significant. Twit Text FOAVip A virus-free cellular model recapitulates several features of severe COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34471195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34471195 #FOAvip English Wikipedia <ref>{{Cite pmid|34471195}}</ref> A virus-free cellular model recapitulates several features of severe COVID-19 #MMPMID34471195 Lavorgna G; Cavalli G; Dagna L; Gregori S; Larcher A; Landoni G; Ciceri F; Montorsi F; Salonia A Sci Rep 2021[Sep]; 11 (1): 17473 PMID34471195show ga As for all newly-emergent pathogens, SARS-CoV-2 presents with a relative paucity of clinical information and experimental models, a situation hampering both the development of new effective treatments and the prediction of future outbreaks. Here, we find that a simple virus-free model, based on publicly available transcriptional data from human cell lines, is surprisingly able to recapitulate several features of the clinically relevant infections. By segregating cell lines (n = 1305) from the CCLE project on the base of their sole angiotensin-converting enzyme 2 (ACE2) mRNA content, we found that overexpressing cells present with molecular features resembling those of at-risk patients, including senescence, impairment of antibody production, epigenetic regulation, DNA repair and apoptosis, neutralization of the interferon response, proneness to an overemphasized innate immune activity, hyperinflammation by IL-1, diabetes, hypercoagulation and hypogonadism. Likewise, several pathways were found to display a differential expression between sexes, with males being in the least advantageous position, thus suggesting that the model could reproduce even the sex-related disparities observed in the clinical outcome of patients with COVID-19. Overall, besides validating a new disease model, our data suggest that, in patients with severe COVID-19, a baseline ground could be already present and, as a consequence, the viral infection might simply exacerbate a variety of latent (or inherent) pre-existing conditions, representing therefore a tipping point at which they become clinically significant. |*Up-Regulation[MESH] |Angiotensin-Converting Enzyme 2/*genetics[MESH] |COVID-19/*genetics/immunology[MESH] |Cell Line[MESH] |Databases, Genetic[MESH] |Female[MESH] |Gene Expression Profiling/*methods[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Male[MESH] |Models, Biological[MESH] |Models, Theoretical[MESH]A virus-free cellular model recapitulates several features of severe C(epmc).pdf DeepDyve Pubget Overpricing