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10.1038/s41564-021-00961-5 http://scihub22266oqcxt.onion/10.1038/s41564-021-00961-5 34465900!8484067!34465900     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2021 ; 6 (10): 1245-1258 Nephropedia Template TP {{tp|p=34465900|t=2021. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome |pdf=|usr=}}{{34465900}} gab.com Text Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34465900 #FOAvip Respiratory failure is associated with increased mortality in COVID-19 patients. There are no validated lower airway biomarkers to predict clinical outcome. We investigated whether bacterial respiratory infections were associated with poor clinical outcome of COVID-19 in a prospective, observational cohort of 589 critically ill adults, all of whom required mechanical ventilation. For a subset of 142 patients who underwent bronchoscopy, we quantified SARS-CoV-2 viral load, analysed the lower respiratory tract microbiome using metagenomics and metatranscriptomics and profiled the host immune response. Acquisition of a hospital-acquired respiratory pathogen was not associated with fatal outcome. Poor clinical outcome was associated with lower airway enrichment with an oral commensal (Mycoplasma salivarium). Increased SARS-CoV-2 abundance, low anti-SARS-CoV-2 antibody response and a distinct host transcriptome profile of the lower airways were most predictive of mortality. Our data provide evidence that secondary respiratory infections do not drive mortality in COVID-19 and clinical management strategies should prioritize reducing viral replication and maximizing host responses to SARS-CoV-2. Twit Text FOAVip Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34465900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34465900 #FOAvip English Wikipedia <ref>{{Cite pmid|34465900}}</ref> Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome #MMPMID34465900 Sulaiman I; Chung M; Angel L; Tsay JJ; Wu BG; Yeung ST; Krolikowski K; Li Y; Duerr R; Schluger R; Thannickal SA; Koide A; Rafeq S; Barnett C; Postelnicu R; Wang C; Banakis S; Perez-Perez L; Shen G; Jour G; Meyn P; Carpenito J; Liu X; Ji K; Collazo D; Labarbiera A; Amoroso N; Brosnahan S; Mukherjee V; Kaufman D; Bakker J; Lubinsky A; Pradhan D; Sterman DH; Weiden M; Heguy A; Evans L; Uyeki TM; Clemente JC; de Wit E; Schmidt AM; Shopsin B; Desvignes L; Wang C; Li H; Zhang B; Forst CV; Koide S; Stapleford KA; Khanna KM; Ghedin E; Segal LN Nat Microbiol 2021[Oct]; 6 (10): 1245-1258 PMID34465900show ga Respiratory failure is associated with increased mortality in COVID-19 patients. There are no validated lower airway biomarkers to predict clinical outcome. We investigated whether bacterial respiratory infections were associated with poor clinical outcome of COVID-19 in a prospective, observational cohort of 589 critically ill adults, all of whom required mechanical ventilation. For a subset of 142 patients who underwent bronchoscopy, we quantified SARS-CoV-2 viral load, analysed the lower respiratory tract microbiome using metagenomics and metatranscriptomics and profiled the host immune response. Acquisition of a hospital-acquired respiratory pathogen was not associated with fatal outcome. Poor clinical outcome was associated with lower airway enrichment with an oral commensal (Mycoplasma salivarium). Increased SARS-CoV-2 abundance, low anti-SARS-CoV-2 antibody response and a distinct host transcriptome profile of the lower airways were most predictive of mortality. Our data provide evidence that secondary respiratory infections do not drive mortality in COVID-19 and clinical management strategies should prioritize reducing viral replication and maximizing host responses to SARS-CoV-2. |*Respiration, Artificial[MESH] |Adaptive Immunity[MESH] |Adult[MESH] |Aged[MESH] |Bacteria/classification/genetics/isolation & purification[MESH] |Bacterial Load[MESH] |Bronchoalveolar Lavage Fluid/immunology/*microbiology/virology[MESH] |COVID-19/immunology/microbiology/mortality/*therapy[MESH] |Critical Illness[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Male[MESH] |Microbiota[MESH] |Middle Aged[MESH] |Odds Ratio[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |Respiratory System/immunology/microbiology/virology[MESH] |SARS-CoV-2/immunology/*pathogenicity[MESH]Microbial signatures in the lower airways of mechanically ventilated C(epmc).pdf DeepDyve Pubget Overpricing