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10.1038/s41421-021-00318-6 http://scihub22266oqcxt.onion/10.1038/s41421-021-00318-6 34465742!8408196!34465742     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34465742&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Discov 2021 ; 7 (1): 76 Nephropedia Template TP {{tp|p=34465742|t=2021. Genome-wide association study of COVID-19 severity among the Chinese population |pdf=|usr=}}{{34465742}} gab.com Text Genome-wide association study of COVID-19 severity among the Chinese population JO: Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=34465742 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). The development of COVID-19 may be the result of a complex interaction between the microbial, environmental, and host genetic components. To reveal genetic determinants of susceptibility to COVID-19 severity in the Chinese population, we performed a genome-wide association study on 885 severe or critical COVID-19 patients (cases) and 546 mild or moderate patients (controls) from two hospitals, Huoshenshan and Union hospitals at Wuhan city in China. We identified two loci on chromosome 11q23.3 and 11q14.2, which are significantly associated with the COVID-19 severity in the meta-analyses of the two cohorts (index rs1712779: odds ratio [OR] = 0.49; 95% confidence interval [CI], 0.38-0.63 for T allele; P = 1.38 x 10(-8); and index rs10831496: OR = 1.66; 95% CI, 1.38-1.98 for A allele; P = 4.04 x 10(-8), respectively). The results for rs1712779 were validated in other two small COVID-19 cohorts in the Asian populations (P = 0.029 and 0.031, respectively). Furthermore, we identified significant eQTL associations for REXO2, C11orf71, NNMT, and CADM1 at 11q23.3, and CTSC at 11q14.2, respectively. In conclusion, our findings highlight two loci at 11q23.3 and 11q14.2 conferring susceptibility to the severity of COVID-19, which might provide novel insights into the pathogenesis and clinical treatment of this disease. Twit Text FOAVip Genome-wide association study of COVID-19 severity among the Chinese population ????Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=34465742 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34465742 #FOAvip English Wikipedia <ref>{{Cite pmid|34465742}}</ref> Genome-wide association study of COVID-19 severity among the Chinese population #MMPMID34465742 Li Y; Ke Y; Xia X; Wang Y; Cheng F; Liu X; Jin X; Li B; Xie C; Liu S; Chen W; Yang C; Niu Y; Jia R; Chen Y; Liu X; Wang Z; Zheng F; Jin Y; Li Z; Yang N; Cao P; Chen H; Ping J; He F; Wang C; Zhou G Cell Discov 2021[Aug]; 7 (1): 76 PMID34465742show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). The development of COVID-19 may be the result of a complex interaction between the microbial, environmental, and host genetic components. To reveal genetic determinants of susceptibility to COVID-19 severity in the Chinese population, we performed a genome-wide association study on 885 severe or critical COVID-19 patients (cases) and 546 mild or moderate patients (controls) from two hospitals, Huoshenshan and Union hospitals at Wuhan city in China. We identified two loci on chromosome 11q23.3 and 11q14.2, which are significantly associated with the COVID-19 severity in the meta-analyses of the two cohorts (index rs1712779: odds ratio [OR] = 0.49; 95% confidence interval [CI], 0.38-0.63 for T allele; P = 1.38 x 10(-8); and index rs10831496: OR = 1.66; 95% CI, 1.38-1.98 for A allele; P = 4.04 x 10(-8), respectively). The results for rs1712779 were validated in other two small COVID-19 cohorts in the Asian populations (P = 0.029 and 0.031, respectively). Furthermore, we identified significant eQTL associations for REXO2, C11orf71, NNMT, and CADM1 at 11q23.3, and CTSC at 11q14.2, respectively. In conclusion, our findings highlight two loci at 11q23.3 and 11q14.2 conferring susceptibility to the severity of COVID-19, which might provide novel insights into the pathogenesis and clinical treatment of this disease. äGenome-wide association study of COVID-19 severity among the Chinese p(epmc).pdf DeepDyve Pubget Overpricing