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10.1126/science.abh1823 http://scihub22266oqcxt.onion/10.1126/science.abh1823 34465633!10026850!34465633     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 374 (6564): eabh1823 Nephropedia Template TP {{tp|p=34465633|t=2021. Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination |pdf=|usr=}}{{34465633}} gab.com Text Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34465633 #FOAvip The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4(+) T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that preexisting spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses. Our results highlight the functional contribution of preexisting spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic or mild COVID-19 disease courses. Twit Text FOAVip Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34465633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34465633 #FOAvip English Wikipedia <ref>{{Cite pmid|34465633}}</ref> Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination #MMPMID34465633 Loyal L; Braun J; Henze L; Kruse B; Dingeldey M; Reimer U; Kern F; Schwarz T; Mangold M; Unger C; Dorfler F; Kadler S; Rosowski J; Gurcan K; Uyar-Aydin Z; Frentsch M; Kurth F; Schnatbaum K; Eckey M; Hippenstiel S; Hocke A; Muller MA; Sawitzki B; Miltenyi S; Paul F; Mall MA; Wenschuh H; Voigt S; Drosten C; Lauster R; Lachman N; Sander LE; Corman VM; Rohmel J; Meyer-Arndt L; Thiel A; Giesecke-Thiel C Science 2021[Oct]; 374 (6564): eabh1823 PMID34465633show ga The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4(+) T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that preexisting spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses. Our results highlight the functional contribution of preexisting spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic or mild COVID-19 disease courses. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Asymptomatic Diseases[MESH] |BNT162 Vaccine[MESH] |CD3 Complex/immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*immunology[MESH] |Cross Reactions[MESH] |Female[MESH] |Humans[MESH] |Immunity[MESH] |Immunodominant Epitopes/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Open Reading Frames[MESH] |Peptide Fragments/immunology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |Vaccination[MESH]Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon(epmc).pdf DeepDyve Pubget Overpricing