Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1096/fj.202100044RRR http://scihub22266oqcxt.onion/10.1096/fj.202100044RRR 34464475!8573545!34464475     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2021 ; 35 (10): e21843 Nephropedia Template TP {{tp|p=34464475|t=2021. The histone methyltransferase Ezh2 restrains macrophage inflammatory responses |pdf=|usr=}}{{34464475}} gab.com Text The histone methyltransferase Ezh2 restrains macrophage inflammatory responses JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=34464475 #FOAvip Robust inflammatory responses are critical to survival following respiratory infection, with current attention focused on the clinical consequences of the Coronavirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 is a prominent target due to the availability of highly specific and efficacious antagonists. However, very little is known about the role of EZH2 in the myeloid lineage. Here, we show EZH2 acts in macrophages to limit inflammatory responses to activation, and in neutrophils for chemotaxis. Selective genetic deletion in macrophages results in a remarkable gain in protection from infection with the prevalent lung pathogen, pneumococcus. In contrast, neutrophils lacking EZH2 showed impaired mobility in response to chemotactic signals, and resulted in increased susceptibility to pneumococcus. In summary, EZH2 shows complex, and divergent roles in different myeloid lineages, likely contributing to the earlier conflicting reports. Compounds targeting EZH2 are likely to impair mucosal immunity; however, they may prove useful for conditions driven by pulmonary neutrophil influx, such as adult respiratory distress syndrome. Twit Text FOAVip The histone methyltransferase Ezh2 restrains macrophage inflammatory responses ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=34464475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34464475 #FOAvip English Wikipedia <ref>{{Cite pmid|34464475}}</ref> The histone methyltransferase Ezh2 restrains macrophage inflammatory responses #MMPMID34464475 Kitchen GB; Hopwood T; Gali Ramamoorthy T; Downton P; Begley N; Hussell T; Dockrell DH; Gibbs JE; Ray DW; Loudon ASI FASEB J 2021[Oct]; 35 (10): e21843 PMID34464475show ga Robust inflammatory responses are critical to survival following respiratory infection, with current attention focused on the clinical consequences of the Coronavirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 is a prominent target due to the availability of highly specific and efficacious antagonists. However, very little is known about the role of EZH2 in the myeloid lineage. Here, we show EZH2 acts in macrophages to limit inflammatory responses to activation, and in neutrophils for chemotaxis. Selective genetic deletion in macrophages results in a remarkable gain in protection from infection with the prevalent lung pathogen, pneumococcus. In contrast, neutrophils lacking EZH2 showed impaired mobility in response to chemotactic signals, and resulted in increased susceptibility to pneumococcus. In summary, EZH2 shows complex, and divergent roles in different myeloid lineages, likely contributing to the earlier conflicting reports. Compounds targeting EZH2 are likely to impair mucosal immunity; however, they may prove useful for conditions driven by pulmonary neutrophil influx, such as adult respiratory distress syndrome. |Animals[MESH] |Cells, Cultured[MESH] |Enhancer of Zeste Homolog 2 Protein/*immunology[MESH] |Inflammation/*immunology[MESH] |Macrophages/cytology/*immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH]The histone methyltransferase Ezh2 restrains macrophage inflammatory r(epmc).pdf DeepDyve Pubget Overpricing