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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 iScience 2021 ; 24 (9): 103030 Nephropedia Template TP
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Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19 #MMPMID34458692
Nassir N; Tambi R; Bankapur A; Al Heialy S; Karuvantevida N; Khansaheb HH; Zehra B; Begum G; Hameid RA; Ahmed A; Deesi Z; Alkhajeh A; Uddin KMF; Akter H; Safizadeh Shabestari SA; Almidani O; Islam A; Gaudet M; Kandasamy RK; Loney T; Tayoun AA; Nowotny N; Woodbury-Smith M; Rahman P; Kuebler WM; Yaseen Hachim M; Casanova JL; Berdiev BK; Alsheikh-Ali A; Uddin M
iScience 2021[Sep]; 24 (9): 103030 PMID34458692show ga
Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases. FCGR3B consistently demarcated MoAM subset in different samples from severe COVID-19 cohorts and in CCL3L1-upregulated cells from nasopharyngeal swabs. In silico findings were validated by upregulation of FCGR3B in nasopharyngeal swabs of severe ICU COVID-19 cases, particularly in older patients and those with comorbidities. Additional lines of evidence from transcriptomic data and in vivo of severe COVID-19 cases suggest that FCGR3B may identify a specific subtype of MoAM in patients with severe COVID-19 that may present a novel biomarker for screening and prognosis, as well as a potential therapeutic target.