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10.3389/fimmu.2021.721738

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.721738
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34456929!8387963!34456929
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suck abstract from ncbi

pmid34456929      Front+Immunol 2021 ; 12 (?): 721738
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  • Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy #MMPMID34456929
  • Bosnjak B; Odak I; Ritter C; Stahl K; Graalmann T; Steinbruck L; Blasczyk R; Falk CS; Schulz TF; Wedemeyer HH; Cornberg M; Ganser A; Forster R; Koenecke C
  • Front Immunol 2021[]; 12 (?): 721738 PMID34456929show ga
  • Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
  • |*B-Lymphocytes/immunology[MESH]
  • |*Immunotherapy, Adoptive[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/complications/*immunology/*therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Immunoglobulins, Intravenous[MESH]
  • |Immunologic Deficiency Syndromes/complications/*immunology[MESH]
  • |Killer Cells, Natural/*immunology[MESH]
  • |Lymphocyte Activation[MESH]
  • |Lymphopoiesis[MESH]
  • |SARS-CoV-2[MESH]
  • |T-Lymphocytes/*immunology[MESH]


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