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10.1016/j.bioorg.2021.105274

http://scihub22266oqcxt.onion/10.1016/j.bioorg.2021.105274
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suck abstract from ncbi


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pmid34455301      Bioorg+Chem 2021 ; 116 (ä): 105274
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  • Screening out anti-inflammatory or anti-viral targets in Xuanfei Baidu Tang through a new technique of reverse finding target #MMPMID34455301
  • Wang Z; Zhang J; Zhan J; Gao H
  • Bioorg Chem 2021[Nov]; 116 (ä): 105274 PMID34455301show ga
  • Traditional Chinese herbal compound prescription in Xuanfei Baidu Tang (XBT) has obvious effects in the treatment of COVID-19. However, its effective compounds and targets for the treatment of COVID-19 remain unclear. Computer-Aided Drug Design is used to virtually screen out the anti-inflammatory or anti-viral compounds in XBT, and predict the potential targets by Discovery Studio 2020. Then, we searched for COVID-19 targets using Genecards databases and Protein Data Bank (PDB) databases and compared them to identify targets that were common to both. Finally, the target we screened out is: TP53 (Tumor Protein P53). This article also shows that XBT in the treatment of COVID-19 works in a multi-link and overall synergistic manner. Our results will help to design the new drugs for COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/chemistry/*pharmacology[MESH]
  • |Antiviral Agents/chemistry/*pharmacology[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Drugs, Chinese Herbal/chemistry/*pharmacology[MESH]
  • |Humans[MESH]
  • |Medicine, Chinese Traditional[MESH]
  • |Molecular Structure[MESH]
  • |SARS-CoV-2/*drug effects/metabolism[MESH]


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