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10.1016/j.jbior.2021.100822 http://scihub22266oqcxt.onion/10.1016/j.jbior.2021.100822 34454870!8375248!34454870     free     free     free       Adv+Biol+Regul 2021 ; 81 (ä): 100822 Nephropedia Template TP {{tp|p=34454870|t=2021. The case of complement inhibitors |pdf=|usr=}}{{34454870}} gab.com Text The case of complement inhibitors JO: Adv Biol Regul http://www.kidney.de/pget.php?&tw=1&pmid=34454870 #FOAvip Severe COVID-19 is characterized by lung and multiorgan inflammation and coagulation in the presence of overactivation of the complement system. Complement is a double edged-sward in SARS-Cov-2 infection. On one hand, it can control the viral infection in milder cases, on the other hand in cases with severe and prolonged infection massive complement activation occurs, which can intensify lung and systemic inflammation and promote a procoagulant and prothrombotic state. Several uncontrolled studies and controlled clinical trials with different complement inhibitors have been performed and others are ongoing. Results are promising in some but negative in others. Further studies are required to elucidate the benefit to risk profile of complement inhibitors in COVID-19 patients at different stages of the disease and to clarify the best targets in the complement cascade. Twit Text FOAVip The case of complement inhibitors ????Adv Biol Regul http://www.kidney.de/pget.php?&tw=1&pmid=34454870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34454870 #FOAvip English Wikipedia <ref>{{Cite pmid|34454870}}</ref> The case of complement inhibitors #MMPMID34454870 Noris M Adv Biol Regul 2021[Aug]; 81 (ä): 100822 PMID34454870show ga Severe COVID-19 is characterized by lung and multiorgan inflammation and coagulation in the presence of overactivation of the complement system. Complement is a double edged-sward in SARS-Cov-2 infection. On one hand, it can control the viral infection in milder cases, on the other hand in cases with severe and prolonged infection massive complement activation occurs, which can intensify lung and systemic inflammation and promote a procoagulant and prothrombotic state. Several uncontrolled studies and controlled clinical trials with different complement inhibitors have been performed and others are ongoing. Results are promising in some but negative in others. Further studies are required to elucidate the benefit to risk profile of complement inhibitors in COVID-19 patients at different stages of the disease and to clarify the best targets in the complement cascade. |*COVID-19 Drug Treatment[MESH] |COVID-19/*blood[MESH] |Complement Activation/*drug effects[MESH] |Complement Inactivating Agents/*therapeutic use[MESH] |Complement System Proteins/*metabolism[MESH] |Humans[MESH] |Lung/metabolism/pathology[MESH] |SARS-CoV-2/*metabolism[MESH]The case of complement inhibitors (epmc).pdf DeepDyve Pubget Overpricing