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10.1016/j.coviro.2021.08.004

http://scihub22266oqcxt.onion/10.1016/j.coviro.2021.08.004
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suck abstract from ncbi


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pmid34454352      Curr+Opin+Virol 2021 ; 50 (ä): 119-127
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  • Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19? #MMPMID34454352
  • Zanoni I
  • Curr Opin Virol 2021[Oct]; 50 (ä): 119-127 PMID34454352show ga
  • Type I and type III interferons are among the most potent anti-viral cytokines produced by the immune system. The recent outbreak of SARS-CoV-2, which causes COVID-19, underscores the vital role of these cytokines in controlling the virus and dictating disease severity. Here we delineate the pathways that lead to interferon production in response to SARS-CoV-2 encounter, and elucidate how this virus hinders the production and action of these cytokines; we also highlight that these interferon families serve protective as well as detrimental roles in patients with COVID-19, and conclude that a better understanding of the time, dose, localization, and activity of specific members of the interferon families is imperative for designing more efficient therapeutic interventions against this disease.
  • |*SARS-CoV-2[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*immunology[MESH]
  • |Humans[MESH]


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