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10.1007/s12104-021-10047-2

http://scihub22266oqcxt.onion/10.1007/s12104-021-10047-2
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suck abstract from ncbi


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pmid34453696      Biomol+NMR+Assign 2021 ; 15 (2): 467-474
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  • (1)H, (13)C and (15)N assignment of stem-loop SL1 from the 5 -UTR of SARS-CoV-2 #MMPMID34453696
  • Richter C; Hohmann KF; Toews S; Mathieu D; Altincekic N; Bains JK; Binas O; Ceylan B; Duchardt-Ferner E; Ferner J; Furtig B; Grun JT; Hengesbach M; Hymon D; Jonker HRA; Knezic B; Korn SM; Landgraf T; Lohr F; Peter SA; Pyper DJ; Qureshi NS; Schlundt A; Schnieders R; Stirnal E; Sudakov A; Vogele J; Weigand JE; Wirmer-Bartoschek J; Witt K; Wohnert J; Schwalbe H; Wacker A
  • Biomol NMR Assign 2021[Oct]; 15 (2): 467-474 PMID34453696show ga
  • The stem-loop (SL1) is the 5'-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7-33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is conserved among Betacoronaviruses. SL1 is present in genomic SARS-CoV-2 RNA as well as in all subgenomic mRNA species produced by the virus during replication, thus representing a ubiquitous cis-regulatory RNA with potential functions at all stages of the viral life cycle. We present here the (1)H, (13)C and (15)N chemical shift assignment of the 29 nucleotides-RNA construct 5_SL1, which denotes the native 27mer SL1 stabilized by an additional terminal G-C base-pair.
  • |*5' Untranslated Regions[MESH]
  • |*Nuclear Magnetic Resonance, Biomolecular[MESH]
  • |Nucleic Acid Conformation[MESH]
  • |RNA, Spliced Leader[MESH]


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