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10.1038/s12276-021-00658-z http://scihub22266oqcxt.onion/10.1038/s12276-021-00658-z 34453107!8393781!34453107     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2021 ; 53 (8): 1229-1237 Nephropedia Template TP {{tp|p=34453107|t=2021. Mutational spectrum of SARS-CoV-2 during the global pandemic |pdf=|usr=}}{{34453107}} gab.com Text Mutational spectrum of SARS-CoV-2 during the global pandemic JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34453107 #FOAvip Viruses accumulate mutations under the influence of natural selection and host-virus interactions. Through a systematic comparison of 351,525 full viral genome sequences collected during the recent COVID-19 pandemic, we reveal the spectrum of SARS-CoV-2 mutations. Unlike those of other viruses, the mutational spectrum of SARS-CoV-2 exhibits extreme asymmetry, with a much higher rate of C>U than U>C substitutions, as well as a higher rate of G>U than U>G substitutions. This suggests directional genome sequence evolution during transmission. The substantial asymmetry and directionality of the mutational spectrum enable pseudotemporal tracing of SARS-CoV-2 without prior information about the root sequence, collection time, and sampling region. This shows that the viral genome sequences collected in Asia are similar to the original genome sequence. Adjusted estimation of the dN/dS ratio accounting for the asymmetrical mutational spectrum also shows evidence of negative selection on viral genes, consistent with previous reports. Our findings provide deep insights into the mutational processes in SARS-CoV-2 viral infection and advance the understanding of the history and future evolution of the virus. Twit Text FOAVip Mutational spectrum of SARS-CoV-2 during the global pandemic ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34453107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34453107 #FOAvip English Wikipedia <ref>{{Cite pmid|34453107}}</ref> Mutational spectrum of SARS-CoV-2 during the global pandemic #MMPMID34453107 Yi K; Kim SY; Bleazard T; Kim T; Youk J; Ju YS Exp Mol Med 2021[Aug]; 53 (8): 1229-1237 PMID34453107show ga Viruses accumulate mutations under the influence of natural selection and host-virus interactions. Through a systematic comparison of 351,525 full viral genome sequences collected during the recent COVID-19 pandemic, we reveal the spectrum of SARS-CoV-2 mutations. Unlike those of other viruses, the mutational spectrum of SARS-CoV-2 exhibits extreme asymmetry, with a much higher rate of C>U than U>C substitutions, as well as a higher rate of G>U than U>G substitutions. This suggests directional genome sequence evolution during transmission. The substantial asymmetry and directionality of the mutational spectrum enable pseudotemporal tracing of SARS-CoV-2 without prior information about the root sequence, collection time, and sampling region. This shows that the viral genome sequences collected in Asia are similar to the original genome sequence. Adjusted estimation of the dN/dS ratio accounting for the asymmetrical mutational spectrum also shows evidence of negative selection on viral genes, consistent with previous reports. Our findings provide deep insights into the mutational processes in SARS-CoV-2 viral infection and advance the understanding of the history and future evolution of the virus. |COVID-19/*virology[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH] |Mutation[MESH]Mutational spectrum of SARS-CoV-2 during the global pandemic (epmc).pdf DeepDyve Pubget Overpricing