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10.1016/j.antiviral.2021.105167 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2021.105167 34450201!8382594!34450201     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 194 (ä): 105167 Nephropedia Template TP {{tp|p=34450201|t=2021. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target |pdf=|usr=}}{{34450201}} gab.com Text Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34450201 #FOAvip Niemann-Pick type C1 (NPC1) receptor is an endosomal membrane protein that regulates intracellular cholesterol traffic. This protein has been shown to play an important role for several viruses. It has been reported that SARS-CoV-2 enters the cell through plasma membrane fusion and/or endosomal entry upon availability of proteases. However, the whole process is not fully understood yet and additional viral/host factors might be required for viral fusion and subsequent viral replication. Here, we report a novel interaction between the SARS-CoV-2 nucleoprotein (N) and the cholesterol transporter NPC1. Furthermore, we have found that some compounds reported to interact with NPC1, carbazole SC816 and sulfides SC198 and SC073, were able to reduce SARS-CoV-2 viral infection with a good selectivity index in human cell infection models. These findings suggest the importance of NPC1 for SARS-CoV-2 viral infection and a new possible potential therapeutic target to fight against COVID-19. Twit Text FOAVip Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34450201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34450201 #FOAvip English Wikipedia <ref>{{Cite pmid|34450201}}</ref> Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target #MMPMID34450201 Garcia-Dorival I; Cuesta-Geijo MA; Barrado-Gil L; Galindo I; Garaigorta U; Urquiza J; Puerto AD; Campillo NE; Martinez A; Gastaminza P; Gil C; Alonso C Antiviral Res 2021[Oct]; 194 (ä): 105167 PMID34450201show ga Niemann-Pick type C1 (NPC1) receptor is an endosomal membrane protein that regulates intracellular cholesterol traffic. This protein has been shown to play an important role for several viruses. It has been reported that SARS-CoV-2 enters the cell through plasma membrane fusion and/or endosomal entry upon availability of proteases. However, the whole process is not fully understood yet and additional viral/host factors might be required for viral fusion and subsequent viral replication. Here, we report a novel interaction between the SARS-CoV-2 nucleoprotein (N) and the cholesterol transporter NPC1. Furthermore, we have found that some compounds reported to interact with NPC1, carbazole SC816 and sulfides SC198 and SC073, were able to reduce SARS-CoV-2 viral infection with a good selectivity index in human cell infection models. These findings suggest the importance of NPC1 for SARS-CoV-2 viral infection and a new possible potential therapeutic target to fight against COVID-19. |*Biological Transport[MESH] |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Carbazoles/pharmacology[MESH] |Chlorocebus aethiops[MESH] |Endosomes/chemistry/*virology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins[MESH] |Membrane Fusion[MESH] |Niemann-Pick C1 Protein/*analysis[MESH] |SARS-CoV-2/*physiology[MESH] |Vero Cells[MESH]Identification of Niemann-Pick C1 protein as a potential novel SARS-Co(epmc).pdf DeepDyve Pubget Overpricing