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10.3390/cimb43020061

http://scihub22266oqcxt.onion/10.3390/cimb43020061
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suck abstract from ncbi


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pmid34449545      Curr+Issues+Mol+Biol 2021 ; 43 (2): 845-867
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  • Next-Generation Sequencing (NGS) in COVID-19: A Tool for SARS-CoV-2 Diagnosis, Monitoring New Strains and Phylodynamic Modeling in Molecular Epidemiology #MMPMID34449545
  • John G; Sahajpal NS; Mondal AK; Ananth S; Williams C; Chaubey A; Rojiani AM; Kolhe R
  • Curr Issues Mol Biol 2021[Jul]; 43 (2): 845-867 PMID34449545show ga
  • This review discusses the current testing methodologies for COVID-19 diagnosis and explores next-generation sequencing (NGS) technology for the detection of SARS-CoV-2 and monitoring phylogenetic evolution in the current COVID-19 pandemic. The review addresses the development, fundamentals, assay quality control and bioinformatics processing of the NGS data. This article provides a comprehensive review of the obstacles and opportunities facing the application of NGS technologies for the diagnosis, surveillance, and study of SARS-CoV-2 and other infectious diseases. Further, we have contemplated the opportunities and challenges inherent in the adoption of NGS technology as a diagnostic test with real-world examples of its utility in the fight against COVID-19.
  • |COVID-19/diagnosis/epidemiology/genetics/*virology[MESH]
  • |Computational Biology/methods[MESH]
  • |High-Throughput Nucleotide Sequencing/*methods[MESH]
  • |Humans[MESH]
  • |Molecular Epidemiology/methods[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]


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