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10.1016/j.biopha.2021.112067 http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.112067 34449310!8376652!34449310     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2021 ; 142 (ä): 112067 Nephropedia Template TP {{tp|p=34449310|t=2021. MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients |pdf=|usr=}}{{34449310}} gab.com Text MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=34449310 #FOAvip Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles. Twit Text FOAVip MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=34449310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34449310 #FOAvip English Wikipedia <ref>{{Cite pmid|34449310}}</ref> MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients #MMPMID34449310 D Avila-Mesquita C; Couto AES; Campos LCB; Vasconcelos TF; Michelon-Barbosa J; Corsi CAC; Mestriner F; Petroski-Moraes BC; Garbellini-Diab MJ; Couto DMS; Jordani MC; Ferro D; Sbragia L; Joviliano EE; Evora PR; Carvalho Santana R; Martins-Filho OA; Polonis K; Menegueti MG; Ribeiro MS; Auxiliadora-Martins M; Becari C Biomed Pharmacother 2021[Oct]; 142 (ä): 112067 PMID34449310show ga Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles. |*COVID-19/blood/diagnosis/mortality/physiopathology[MESH] |*Hospital Mortality[MESH] |*Hypertension/diagnosis/epidemiology[MESH] |*Matrix Metalloproteinase 2/analysis/blood[MESH] |*Matrix Metalloproteinase 9/analysis/blood[MESH] |Age Factors[MESH] |Body Mass Index[MESH] |Brazil/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units/*statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Mortality[MESH] |Predictive Value of Tests[MESH] |Prognosis[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH]MMP-2 and MMP-9 levels in plasma are altered and associated with morta(epmc).pdf DeepDyve Pubget Overpricing