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10.3389/fendo.2021.703905

http://scihub22266oqcxt.onion/10.3389/fendo.2021.703905
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suck abstract from ncbi


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pmid34447352      Front+Endocrinol+(Lausanne) 2021 ; 12 (ä): 703905
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  • COVID-19 Pandemic and Pediatric Type 1 Diabetes: No Significant Change in Glycemic Control During The Pandemic Lockdown of 2020 #MMPMID34447352
  • Nwosu BU; Al-Halbouni L; Parajuli S; Jasmin G; Zitek-Morrison E; Barton BA
  • Front Endocrinol (Lausanne) 2021[]; 12 (ä): 703905 PMID34447352show ga
  • IMPORTANCE: There is no consensus on the impact of the 2020 COVID-19 pandemic lockdown on glycemic control in children and adolescents with type 1 diabetes (T1D) in the US. AIM: To determine the impact of the pandemic lockdown of March 15th through July 6(th), 2020 on glycemic control after controlling for confounders. SUBJECTS AND METHODS: An observational study of 110 subjects of mean age 14.8 +/- 4.9 years(y), [male 15.4 +/- 4.0y, (n=57); female 14.1 +/- 3.8y, (n=53), p=0.07] with T1D of 6.31 +/- 4.3y (95% CI 1.0-19.7y). Data were collected at 1-4 months before the lockdown and 1-4 months following the lifting of the lockdown at their first post-lockdown clinic visit. RESULTS: There was no significant change in A1c between the pre- and post-pandemic lockdown periods, 0.18 +/- 1.2%, (95% CI -0.05 to 0.41), p=0.13. There were equally no significant differences in A1c between the male and female subjects, -0.16 +/- 1.2 vs -0.19 +/- 1.2%, p=0.8; insulin pump users and non-pump users, -0.25 +/- 1.0 vs -0.12 +/- 1.4%, p=0.5; and pubertal vs prepubertal subjects, 0.18 +/- 1.3 vs -0.11 +/- 0.3%, p=0.6. The significant predictors of decrease in A1c were pre-lockdown A1c (p<0.0001) and the use of CGM (p=0.019). The CGM users had significant reductions in point-of-care A1c (0.4 +/- 0.6%, p=0.0012), the CGM-estimated A1c (p=0.0076), mean glucose concentration (p=0.022), a significant increase in sensor usage (p=0.012), with no change in total daily dose of insulin (TDDI). The non-CGM users had significantly increased TDDI (p<0.0001) but no change in HbA1c, 0.06 +/- 1.8%, p=0.86. CONCLUSIONS: There was no change in glycemic control during the pandemic lockdown of 2020 in US children.
  • |*Glycemic Control/instrumentation/methods[MESH]
  • |*Quarantine/organization & administration[MESH]
  • |Adolescent[MESH]
  • |Age Factors[MESH]
  • |Blood Glucose Self-Monitoring/instrumentation/methods[MESH]
  • |Blood Glucose/metabolism[MESH]
  • |COVID-19/*epidemiology/prevention & control[MESH]
  • |Child[MESH]
  • |Communicable Disease Control/organization & administration[MESH]
  • |Diabetes Mellitus, Type 1/*blood/epidemiology/therapy[MESH]
  • |Female[MESH]
  • |Glycated Hemoglobin/metabolism[MESH]
  • |History, 21st Century[MESH]
  • |Humans[MESH]
  • |Insulin Infusion Systems[MESH]
  • |Insulin/administration & dosage[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Retrospective Studies[MESH]


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