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10.4103/aian.AIAN_1303_20

http://scihub22266oqcxt.onion/10.4103/aian.AIAN_1303_20
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34446994!8370175!34446994
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suck abstract from ncbi

pmid34446994      Ann+Indian+Acad+Neurol 2021 ; 24 (3): 339-346
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  • Guillian--Barre Syndrome in Patients with SARS-CoV-2: A Multicentric Study from Maharashtra, India #MMPMID34446994
  • Dhamne MC; Benny R; Singh R; Pande A; Agarwal P; Wagh S; Oak P; Lakhotia A; Godge Y; Bolegave V; Doshi D; Patidar Y; Venkatachalam A; Pujara B; Borse S; Makhija P; Khadilkar S
  • Ann Indian Acad Neurol 2021[May]; 24 (3): 339-346 PMID34446994show ga
  • BACKGROUND: Guillian--Barre' Syndrome (GBS) has been shown to be associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The aim of our study was to study the clinical profile and outcomes of GBS in COVID-19 from the Western region of India, the State of Maharashtra. METHODS: This was a retrospective, multicenter observation study from different hospitals in Maharashtra beginning from March 2020 until November 2020. RESULTS: We report 42 patients with COVID-19 GBS. Mean age was 59 years (range, 24--85 years). 31/42 (73.8%) were men. GBS was the presenting symptom in 14/42 (33%), while six of them remained asymptomatic for COVID-19 despite positive SARS-CoV-2 on nasopharyngeal swab reverse transcriptase polymerase chain reaction. The median interval between COVID-19 and GBS was 14 days (SD + 11), with minimum of 1 and maximum 40 days. Clinical presentation was like that of typical GBS. Electrophysiological studies showed a predominant demyelinating pattern in 25/42 (59.5%). Inflammatory markers were elevated in 35/42 (83.3%) and 38/42 (90.5%) had an Abnormal high-resolution CT (HRCT) chest. 14/42 (33.3%) patients required a ventilator, with nine deaths. Intravenous immunoglobulin was the mainstay of treatment for GBS. Majority had a good outcome and were walking independently or with minimal support at discharge. In subgroup analysis, the postinfectious group had a better outcome than the parainfectious group. CONCLUSION: GBS in COVID-19 occurs as both parainfectious and postinfectious GBS. Parainfectious GBS needs more rigorous monitoring and may benefit from COVID-19 specific treatment. Routine screening for SARS-CoV-2 should be implemented in patients with GBS in view of the ongoing pandemic.
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