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  • AHR signaling is induced by infection with coronaviruses #MMPMID34446714
  • Giovannoni F; Li Z; Remes-Lenicov F; Davola ME; Elizalde M; Paletta A; Ashkar AA; Mossman KL; Dugour AV; Figueroa JM; Barquero AA; Ceballos A; Garcia CC; Quintana FJ
  • Nat Commun 2021[Aug]; 12 (1): 5148 PMID34446714show ga
  • Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue viruses; AHR antagonists boost antiviral immunity, decrease viral titers and ameliorate Zika-induced pathology in vivo. Here we report that AHR is activated by infection with different coronaviruses, potentially impacting antiviral immunity and lung epithelial cells. Indeed, the analysis of single-cell RNA-seq from lung tissue detected increased expression of AHR and AHR transcriptional targets, suggesting AHR signaling activation in SARS-CoV-2-infected epithelial cells from COVID-19 patients. Moreover, we detected an association between AHR expression and viral load in SARS-CoV-2 infected patients. Finally, we found that the pharmacological inhibition of AHR suppressed the replication in vitro of one of the causative agents of the common cold, HCoV-229E, and the causative agent of the COVID-19 pandemic, SARS-CoV-2. Taken together, these findings suggest that AHR activation is a common strategy used by coronaviruses to evade antiviral immunity and promote viral replication, which may also contribute to lung pathology. Future studies should further evaluate the potential of AHR as a target for host-directed antiviral therapy.
  • |*Signal Transduction[MESH]
  • |COVID-19/genetics/metabolism/virology[MESH]
  • |Coronavirus Infections/genetics/*metabolism/virology[MESH]
  • |Coronavirus/*physiology[MESH]
  • |Epithelial Cells/metabolism/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Receptors, Aryl Hydrocarbon/genetics/*metabolism[MESH]
  • |SARS-CoV-2/physiology[MESH]

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  • suck abstract from ncbi

    5148 1.12 2021