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10.1038/s41467-021-25412-x http://scihub22266oqcxt.onion/10.1038/s41467-021-25412-x 34446714!8390748!34446714     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 5148 Nephropedia Template TP {{tp|p=34446714|t=2021. AHR signaling is induced by infection with coronaviruses |pdf=|usr=}}{{34446714}} gab.com Text AHR signaling is induced by infection with coronaviruses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34446714 #FOAvip Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue viruses; AHR antagonists boost antiviral immunity, decrease viral titers and ameliorate Zika-induced pathology in vivo. Here we report that AHR is activated by infection with different coronaviruses, potentially impacting antiviral immunity and lung epithelial cells. Indeed, the analysis of single-cell RNA-seq from lung tissue detected increased expression of AHR and AHR transcriptional targets, suggesting AHR signaling activation in SARS-CoV-2-infected epithelial cells from COVID-19 patients. Moreover, we detected an association between AHR expression and viral load in SARS-CoV-2 infected patients. Finally, we found that the pharmacological inhibition of AHR suppressed the replication in vitro of one of the causative agents of the common cold, HCoV-229E, and the causative agent of the COVID-19 pandemic, SARS-CoV-2. Taken together, these findings suggest that AHR activation is a common strategy used by coronaviruses to evade antiviral immunity and promote viral replication, which may also contribute to lung pathology. Future studies should further evaluate the potential of AHR as a target for host-directed antiviral therapy. Twit Text FOAVip AHR signaling is induced by infection with coronaviruses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34446714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34446714 #FOAvip English Wikipedia <ref>{{Cite pmid|34446714}}</ref> AHR signaling is induced by infection with coronaviruses #MMPMID34446714 Giovannoni F; Li Z; Remes-Lenicov F; Davola ME; Elizalde M; Paletta A; Ashkar AA; Mossman KL; Dugour AV; Figueroa JM; Barquero AA; Ceballos A; Garcia CC; Quintana FJ Nat Commun 2021[Aug]; 12 (1): 5148 PMID34446714show ga Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue viruses; AHR antagonists boost antiviral immunity, decrease viral titers and ameliorate Zika-induced pathology in vivo. Here we report that AHR is activated by infection with different coronaviruses, potentially impacting antiviral immunity and lung epithelial cells. Indeed, the analysis of single-cell RNA-seq from lung tissue detected increased expression of AHR and AHR transcriptional targets, suggesting AHR signaling activation in SARS-CoV-2-infected epithelial cells from COVID-19 patients. Moreover, we detected an association between AHR expression and viral load in SARS-CoV-2 infected patients. Finally, we found that the pharmacological inhibition of AHR suppressed the replication in vitro of one of the causative agents of the common cold, HCoV-229E, and the causative agent of the COVID-19 pandemic, SARS-CoV-2. Taken together, these findings suggest that AHR activation is a common strategy used by coronaviruses to evade antiviral immunity and promote viral replication, which may also contribute to lung pathology. Future studies should further evaluate the potential of AHR as a target for host-directed antiviral therapy. |*Signal Transduction[MESH] |COVID-19/genetics/metabolism/virology[MESH] |Coronavirus Infections/genetics/*metabolism/virology[MESH] |Coronavirus/*physiology[MESH] |Epithelial Cells/metabolism/virology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Receptors, Aryl Hydrocarbon/genetics/*metabolism[MESH]AHR signaling is induced by infection with coronaviruses (epmc).pdf DeepDyve Pubget Overpricing