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10.1038/s41467-021-25040-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-25040-5 34446707!8390461!34446707     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34446707&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 5152 Nephropedia Template TP {{tp|p=34446707|t=2021. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |pdf=|usr=}}{{34446707}} gab.com Text Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34446707 #FOAvip The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results of comparative lower respiratory tract transcriptional profiling of tracheal aspirate from 52 critically ill patients with ARDS from COVID-19 or from other etiologies, as well as controls without ARDS. In contrast to a "cytokine storm," we observe reduced proinflammatory gene expression in COVID-19 ARDS when compared to ARDS due to other causes. COVID-19 ARDS is characterized by a dysregulated host response with increased PTEN signaling and elevated expression of genes with non-canonical roles in inflammation and immunity. In silico analysis of gene expression identifies several candidate drugs that may modulate gene expression in COVID-19 ARDS, including dexamethasone and granulocyte colony stimulating factor. Compared to ARDS due to other types of viral pneumonia, COVID-19 is characterized by impaired interferon-stimulated gene (ISG) expression. The relationship between SARS-CoV-2 viral load and expression of ISGs is decoupled in patients with COVID-19 ARDS when compared to patients with mild COVID-19. In summary, assessment of host gene expression in the lower airways of patients reveals distinct immunological features of COVID-19 ARDS. Twit Text FOAVip Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34446707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34446707 #FOAvip English Wikipedia <ref>{{Cite pmid|34446707}}</ref> Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS #MMPMID34446707 Sarma A; Christenson SA; Byrne A; Mick E; Pisco AO; DeVoe C; Deiss T; Ghale R; Zha BS; Tsitsiklis A; Jauregui A; Moazed F; Detweiler AM; Spottiswoode N; Sinha P; Neff N; Tan M; Serpa PH; Willmore A; Ansel KM; Wilson JG; Leligdowicz A; Siegel ER; Sirota M; DeRisi JL; Matthay MA; Hendrickson CM; Kangelaris KN; Krummel MF; Woodruff PG; Erle DJ; Calfee CS; Langelier CR Nat Commun 2021[Aug]; 12 (1): 5152 PMID34446707show ga The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results of comparative lower respiratory tract transcriptional profiling of tracheal aspirate from 52 critically ill patients with ARDS from COVID-19 or from other etiologies, as well as controls without ARDS. In contrast to a "cytokine storm," we observe reduced proinflammatory gene expression in COVID-19 ARDS when compared to ARDS due to other causes. COVID-19 ARDS is characterized by a dysregulated host response with increased PTEN signaling and elevated expression of genes with non-canonical roles in inflammation and immunity. In silico analysis of gene expression identifies several candidate drugs that may modulate gene expression in COVID-19 ARDS, including dexamethasone and granulocyte colony stimulating factor. Compared to ARDS due to other types of viral pneumonia, COVID-19 is characterized by impaired interferon-stimulated gene (ISG) expression. The relationship between SARS-CoV-2 viral load and expression of ISGs is decoupled in patients with COVID-19 ARDS when compared to patients with mild COVID-19. In summary, assessment of host gene expression in the lower airways of patients reveals distinct immunological features of COVID-19 ARDS. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*genetics/immunology/virology[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Critical Illness[MESH] |Cytokines/genetics/immunology[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |RNA/*genetics/metabolism[MESH] |Respiratory Distress Syndrome/*genetics/immunology/virology[MESH] |SARS-CoV-2/physiology[MESH] |Sequence Analysis, RNA[MESH]Tracheal aspirate RNA sequencing identifies distinct immunological fea(epmc).pdf DeepDyve Pubget Overpricing