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10.3390/diagnostics11081439 http://scihub22266oqcxt.onion/10.3390/diagnostics11081439 34441374!8394367!34441374     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagnostics+(Basel) 2021 ; 11 (8): ä Nephropedia Template TP {{tp|p=34441374|t=2021. Comparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-gamma ELISpot |pdf=|usr=}}{{34441374}} gab.com Text Comparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-gamma ELISpot JO: Diagnostics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34441374 #FOAvip Herd immunity is essential to control severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), especially in immunocompromised patients. Convalescent individuals should be vaccinated later due to vaccine shortage, as studies show that neutralizing antibodies generated during infection are stable for at least 6 months. Cellular immunity is also detectable for months. However, there is evidence of cross-reactivity of T cells with human endemic coronaviruses (HCoVs). Here, we show that cross-reactivity-which may prevent the specific detection of SARS-CoV-2-specific T cell responses-can be avoided if cells are stimulated with the N-terminus of the spike protein in IFN-gamma ELISpot. In contrast to previous studies, we examined T-cell responses against all four known HCoVs using IFN-gamma ELISpot in 19 convalescent volunteers and 10 fully vaccinated volunteers. In addition, we performed Spearman analyses to detect cross-reactivity of T cells. We observed no correlation between T-cell responses against SARS-CoV-2 and human endemic coronaviruses, either in the whole cohort or in the individual groups. The use of the respective stimuli could lead to a more accurate assessment of cellular immunity in recovered individuals. This testing procedure could help to define the best time point at which convalescents should receive SARS-CoV-2 vaccination. Twit Text FOAVip Comparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-gamma ELISpot ????Diagnostics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34441374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34441374 #FOAvip English Wikipedia <ref>{{Cite pmid|34441374}}</ref> Comparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-gamma ELISpot #MMPMID34441374 Thummler L; Schwarzkopf S; Knop D; Ross JA; Berg V; Horn PA; Lindemann M Diagnostics (Basel) 2021[Aug]; 11 (8): ä PMID34441374show ga Herd immunity is essential to control severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), especially in immunocompromised patients. Convalescent individuals should be vaccinated later due to vaccine shortage, as studies show that neutralizing antibodies generated during infection are stable for at least 6 months. Cellular immunity is also detectable for months. However, there is evidence of cross-reactivity of T cells with human endemic coronaviruses (HCoVs). Here, we show that cross-reactivity-which may prevent the specific detection of SARS-CoV-2-specific T cell responses-can be avoided if cells are stimulated with the N-terminus of the spike protein in IFN-gamma ELISpot. In contrast to previous studies, we examined T-cell responses against all four known HCoVs using IFN-gamma ELISpot in 19 convalescent volunteers and 10 fully vaccinated volunteers. In addition, we performed Spearman analyses to detect cross-reactivity of T cells. We observed no correlation between T-cell responses against SARS-CoV-2 and human endemic coronaviruses, either in the whole cohort or in the individual groups. The use of the respective stimuli could lead to a more accurate assessment of cellular immunity in recovered individuals. This testing procedure could help to define the best time point at which convalescents should receive SARS-CoV-2 vaccination. äComparison of SARS-CoV-2- and HCoV-Specific T Cell Response Using IFN-(epmc).pdf DeepDyve Pubget Overpricing