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10.3390/diagnostics11081309

http://scihub22266oqcxt.onion/10.3390/diagnostics11081309
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34441244!8392709!34441244
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suck abstract from ncbi


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pmid34441244      Diagnostics+(Basel) 2021 ; 11 (8): ä
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  • Forecasting COVID-19 Severity by Intelligent Optical Fingerprinting of Blood Samples #MMPMID34441244
  • Faria SP; Carpinteiro C; Pinto V; Rodrigues SM; Alves J; Marques F; Lourenco M; Santos PH; Ramos A; Cardoso MJ; Guimaraes JT; Rocha S; Sampaio P; Clifton DA; Mumtaz M; Paiva JS
  • Diagnostics (Basel) 2021[Jul]; 11 (8): ä PMID34441244show ga
  • Forecasting COVID-19 disease severity is key to supporting clinical decision making and assisting resource allocation, particularly in intensive care units (ICUs). Here, we investigated the utility of time- and frequency-related features of the backscattered signal of serum patient samples to predict COVID-19 disease severity immediately after diagnosis. ICU admission was the primary outcome used to define disease severity. We developed a stacking ensemble machine learning model including the backscattered signal features (optical fingerprint), patient comorbidities, and age (AUROC = 0.80), which significantly outperformed the predictive value of clinical and laboratory variables available at hospital admission (AUROC = 0.71). The information derived from patient optical fingerprints was not strongly correlated with any clinical/laboratory variable, suggesting that optical fingerprinting brings unique information for COVID-19 severity risk assessment. Optical fingerprinting is a label-free, real-time, and low-cost technology that can be easily integrated as a front-line tool to facilitate the triage and clinical management of COVID-19 patients.
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