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10.3390/biom11081202

http://scihub22266oqcxt.onion/10.3390/biom11081202
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34439868!8391528!34439868
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suck abstract from ncbi


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pmid34439868      Biomolecules 2021 ; 11 (8): ä
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  • Cytokine Storms in the Course of COVID-19 and Haemophagocytic Lymphohistiocytosis in Pregnant and Postpartum Women #MMPMID34439868
  • Obuchowska A; Standylo A; Obuchowska K; Kimber-Trojnar Z; Leszczynska-Gorzelak B
  • Biomolecules 2021[Aug]; 11 (8): ä PMID34439868show ga
  • The term 'cytokine storm' (CS) applies to a pathological autoimmune reaction when the interactions that lead to cytokine production are destabilised and may even lead to death. CS may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, we present our analysis of certain pathological processes that induce a CS in pregnant and postpartum women. We draw our attention to the similarities between the severe course of Coronavirus Disease 2019 (COVID-19) and haemophagocytic lymphohistiocytosis (HLH). It is noteworthy that many of the criteria used to diagnose HLH are described as COVID-19 mortality predictors. Cytokine storms are considered to be an important cause of death in patients with the severe course of SARS-CoV-2 infection. Due to the fact that pregnant women are in an immunosuppressive state, viral pulmonary infections are more perilous for them-possible risks include miscarriage, intrauterine growth restriction or birth before the term; sometimes ventilation support is needed. HLH should be considered in pregnant and puerperal women suffering from moderately severe to severe COVID-19 and presenting with: fever unresponsive to antibiotic therapy, cytopenia, hepatitis and hyperferritinaemia. The HLH disorder is rare and difficult to diagnose; however, its early detection could reduce patient mortality.
  • |COVID-19/complications/immunology/*pathology[MESH]
  • |Cytokine Release Syndrome/etiology/immunology/*pathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphohistiocytosis, Hemophagocytic/etiology/immunology/*pathology[MESH]
  • |Postpartum Period[MESH]
  • |Pregnancy[MESH]


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