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10.3390/antibiotics10080942

http://scihub22266oqcxt.onion/10.3390/antibiotics10080942
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34438992!8389044!34438992
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suck abstract from ncbi


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pmid34438992      Antibiotics+(Basel) 2021 ; 10 (8): ä
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  • Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials #MMPMID34438992
  • Sousa SA; Feliciano JR; Pita T; Soeiro CF; Mendes BL; Alves LG; Leitao JH
  • Antibiotics (Basel) 2021[Aug]; 10 (8): ä PMID34438992show ga
  • Nosocomial bacterial infections are associated with high morbidity and mortality, posing a huge burden to healthcare systems worldwide. The ongoing COVID-19 pandemic, with the raised hospitalization of patients and the increased use of antimicrobial agents, boosted the emergence of difficult-to-treat multidrug-resistant (MDR) bacteria in hospital settings. Therefore, current available antibiotic treatments often have limited or no efficacy against nosocomial bacterial infections, and novel therapeutic approaches need to be considered. In this review, we analyze current antibacterial alternatives under investigation, focusing on metal-based complexes, antimicrobial peptides, and antisense antimicrobial therapeutics. The association of new compounds with older, commercially available antibiotics and the repurposing of existing drugs are also revised in this work.
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