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10.1038/s41598-021-96462-w http://scihub22266oqcxt.onion/10.1038/s41598-021-96462-w 34433867!8387424!34433867     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34433867.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2021 ; 11 (1): 17146 Nephropedia Template TP {{tp|p=34433867|t=2021. Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses |pdf=|usr=}}{{34433867}} gab.com Text Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34433867 #FOAvip The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and COVID-19 disease progression. In this study, we show that SARS-CoV-2 can establish a robust infection in HEK293T cells that overexpress human angiotensin-converting enzyme 2 (hACE2) without triggering significant host immune response. Instead, endoplasmic reticulum stress and unfolded protein response-related pathways are predominantly activated. By comparing our data with published transcriptome of SARS-CoV-2 infection in other cell lines, we found that the expression level of hACE2 directly correlates with the viral load in infected cells but not with the scale of immune responses. Only cells that express high level of endogenous hACE2 exhibit an extensive immune attack even with a low viral load. Therefore, the infection route may be critical for the extent of the immune response, thus the severity of COVID-19 disease status. Twit Text FOAVip Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34433867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34433867 #FOAvip English Wikipedia <ref>{{Cite pmid|34433867}}</ref> Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses #MMPMID34433867 Sun G; Cui Q; Garcia G Jr; Wang C; Zhang M; Arumugaswami V; Riggs AD; Shi Y Sci Rep 2021[Aug]; 11 (1): 17146 PMID34433867show ga The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and COVID-19 disease progression. In this study, we show that SARS-CoV-2 can establish a robust infection in HEK293T cells that overexpress human angiotensin-converting enzyme 2 (hACE2) without triggering significant host immune response. Instead, endoplasmic reticulum stress and unfolded protein response-related pathways are predominantly activated. By comparing our data with published transcriptome of SARS-CoV-2 infection in other cell lines, we found that the expression level of hACE2 directly correlates with the viral load in infected cells but not with the scale of immune responses. Only cells that express high level of endogenous hACE2 exhibit an extensive immune attack even with a low viral load. Therefore, the infection route may be critical for the extent of the immune response, thus the severity of COVID-19 disease status. |*Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |*COVID-19/immunology/virology/genetics[MESH] |*Immunity, Innate/genetics[MESH] |*SARS-CoV-2/immunology/genetics/physiology[MESH] |*Transcriptome[MESH] |*Viral Load[MESH] |Endoplasmic Reticulum Stress/immunology/genetics[MESH] |Gene Expression Profiling[MESH] |HEK293 Cells[MESH] |Humans[MESH]Comparative transcriptomic analysis of SARS-CoV-2 infected cell model (epmc).pdf DeepDyve Pubget Overpricing