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  • A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome #MMPMID34433827
  • Kim D; Kim S; Park J; Chang HR; Chang J; Ahn J; Park H; Park J; Son N; Kang G; Kim J; Kim K; Park MS; Kim YK; Baek D
  • Nat Commun 2021[Aug]; 12 (1): 5120 PMID34433827show ga
  • COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 million deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on the human genome remain unexplored. Here, we report a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly, substantial amount of SARS-CoV-2 translation initiates at a novel translation initiation site (TIS) located in the leader sequence, termed TIS-L. Since TIS-L is included in all the genomic and subgenomic RNAs, the SARS-CoV-2 translatome may be regulated by a sophisticated interplay between TIS-L and downstream TISs. TIS-L functions as a strong translation enhancer for ORF S, and as translation suppressors for most of the other ORFs. Our global temporal atlas provides compelling insight into unique regulation of the SARS-CoV-2 translatome and helps comprehensively evaluate its impact on the human genome.
  • |*Protein Biosynthesis[MESH]
  • |*Transcriptome[MESH]
  • |COVID-19/*virology[MESH]
  • |Gene Expression Regulation, Viral[MESH]
  • |Genome, Human[MESH]
  • |Humans[MESH]
  • |Open Reading Frames[MESH]
  • |RNA, Viral/genetics/metabolism[MESH]
  • |SARS-CoV-2/*genetics/metabolism[MESH]
  • |Viral Proteins/genetics/metabolism[MESH]

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  • suck abstract from ncbi

    5120 1.12 2021